MCC

Gene Symbol MCC
Entrez Gene 4163
Alt Symbol MCC1
Species Human
Gene Type protein-coding
Description mutated in colorectal cancers
Other Description colorectal mutant cancer protein
Swissprots D3DT05 Q6ZR04 P23508
Accessions EAW48984 EAW48985 EAW48986 EAW48987 P23508 AK096212 BAG53232 AK128596 BAC87521 AK300259 BAH13246 AL359558 AM393612 CAL38488 BC009279 AAH09279 BC018919 AAH18919 BC043431 BX537952 CAD97919 BX647710 CF887436 CR749713 EU831990 ACE87431 EU832083 ACE86745 M62397 AAA52069 XM_005271991 XP_005272048 NM_001085377 NP_001078846 NM_002387 NP_002378
Function Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440}.
Subcellular Location Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
Tissue Specificity Expressed in a variety of tissues.

MCC (A-9) - sc-398216 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCC (A-9): sc-398216. Western blot analysis of MCC expression in non-transfected 293T: sc-117752 (A), human MCC transfected 293T: sc-177522 (B) and HCT-116 (C) whole cell lysates and human liver tissue extract (D).

MCC (1) - sc-135982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
MCC (1): sc-135982. Western blot analysis of MCC expression in human endothelial whole cell lysate.

MCC (D-20) - sc-54094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MCC (H-285) - sc-366411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MCC (K-18) - sc-54095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MCC (P-19) - sc-54096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MCC antibody - ab125920 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MCC antibody (ab125920) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

Anti-MCC antibody - ab103641 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MCC antibody (ab103641) at 1 µg/ml + Mouse lung tissue lysate at 50 µg

Anti-MCC antibody - ab130708 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MCC antibody (ab130708) at 1/100 dilution + U937 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-MCC antibody - ab128637 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MCC antibody (ab128637) at 1 µg/ml + MCF7 cell lysate at 10 µg

Anti-MCC antibody - ab172022 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MCC antibody (ab172022) at 1 µg/mlLane 1 : MCC transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.

Anti-MCC antibody - ab55489 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55489 MCC antibody at 1ug/ml.

Anti-MCC antibody - C-terminal - ab191149 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MCC antibody - C-terminal (ab191149) at 0.5 µg/mlLane 1 : Rat brain lysateLane 2 : 293T cell lysateLane 3 : NIH lysateLane 4 : A549 lysateLane 5 : HepG2 lysate

Anti-MCC Antibody (aa473-501, FITC) - LS-C207229 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa473-501, PE) - LS-C207231 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa473-501, Biotin) - LS-C208965 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa473-501, AP) - LS-C208963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa683-732) - LS-C151506 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCC antibody Western Blot of MCF7.

Anti-MCC Antibody (aa473-501, APC) - LS-C208964 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa473-501, Azide-free, HRP) - LS-C207230 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa31-130, Azide-free) - LS-C327860 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-MCC Antibody - LS-C310959 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa472-501) - LS-C322901 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCC Antibody (aa473-501) - LS-C158111 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MCC Antibody western blot of U937 cell line lysates (35 ug/lane). The MCC antibody detected the MCC protein (arrow).

Anti-MCC Antibody (aa573-590) - LS-C313525 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of MCC antibody. All lanes: Anti-MCC at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug. Lane 2: 293T Whole Cell Lysate at 40ug. Lane 3: NIH Whole Cell Lysate at 40ug. Lane 4: A549 Whole Cell Lysate at 40ug. Lane 5: HEPG2 Whole Cell Lysate at 40ug. Predicted bind size: 93KD. Observed bind size: 93KD.
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