MCC

Gene Symbol MCC
Entrez Gene 4163
Alt Symbol MCC1
Species Human
Gene Type protein-coding
Description mutated in colorectal cancers
Other Description colorectal mutant cancer protein
Swissprots D3DT05 Q6ZR04 P23508
Accessions EAW48984 EAW48985 EAW48986 EAW48987 P23508 AK096212 BAG53232 AK128596 BAC87521 AK300259 BAH13246 AL359558 AM393612 CAL38488 BC009279 AAH09279 BC018919 AAH18919 BC043431 BX537952 CAD97919 BX647710 CF887436 CR749713 EU831990 ACE87431 EU832083 ACE86745 M62397 AAA52069 XM_005271991 XP_005272048 NM_001085377 NP_001078846 NM_002387 NP_002378
Function Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440}.
Subcellular Location Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
Tissue Specificity Expressed in a variety of tissues.

MCC CRISPR/Cas9 KO Plasmid (h) - sc-404248 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC HDR Plasmid (h) - sc-404248-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC Double Nickase Plasmid (h) - sc-404248-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC Double Nickase Plasmid (h2) - sc-404248-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC CRISPR Activation Plasmid (h) - sc-404248-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC CRISPR Activation Plasmid (h2) - sc-404248-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC Lentiviral Activation Particles (h) - sc-404248-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC Lentiviral Activation Particles (h2) - sc-404248-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCC siRNA (h) - sc-106908 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCC shRNA Plasmid (h) - sc-106908-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCC shRNA (h) Lentiviral Particles - sc-106908-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCC RNAi - H00004163-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MCC RNAi - H00004163-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU145701 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN13104 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13104 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MCC siRNA (Human) - CRH2835 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MCC (NM_002387.2) - SHH339143 from Creative biogene

Category siRNA
Species Reactivities Human

Human MCC siRNA - orb263337 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MCC shRNA Plasmid (Human) - CHH2835 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MCC miRNA 3'UTR clone - MiUTR1H-06157 from Creative biogene

Species Reactivities Human
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