MCC

Gene Symbol	MCC
Entrez Gene	4163
Alt Symbol	MCC1
Species	Human
Gene Type	protein-coding
Description	mutated in colorectal cancers
Other Description	colorectal mutant cancer protein
Swissprots	D3DT05 Q6ZR04 P23508
Accessions	EAW48984 EAW48985 EAW48986 EAW48987 P23508 AK096212 BAG53232 AK128596 BAC87521 AK300259 BAH13246 AL359558 AM393612 CAL38488 BC009279 AAH09279 BC018919 AAH18919 BC043431 BX537952 CAD97919 BX647710 CF887436 CR749713 EU831990 ACE87431 EU832083 ACE86745 M62397 AAA52069 XM_005271991 XP_005272048 NM_001085377 NP_001078846 NM_002387 NP_002378
Function	Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440}.
Subcellular Location	Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
Tissue Specificity	Expressed in a variety of tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MCC full length protein - ab158865 from Abcam Category Protein Source Wheat germ Species Human

Human MCC protein fragment - ab158866 from Abcam Category Protein Source Wheat germ Species Human

MCC Antibody Blocking Peptide - LS-E4865 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCC Antibody Blocking Peptide - LS-E22999 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MCC Protein - H00004163-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MCC Protein - H00004163-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MCC-Antibody-Center-Blocking-Peptide - BP17244c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MCC - H00004163-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MCC - H00004163-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MCC - H00004163-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MCC - H00004163-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MCC fusion protein - Ag2089 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MCC (88-103) - GWB-9F5140 from Genway Biotech Category Peptide Prices $130.00, $520.00 Sizes 1 mg, 5 mg

Recombinant Human MCC, GST-tagged - MCC-774H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Colorectal mutant cancer protein(MCC) ,partial - CSB-YP013571HU CSB-EP013571HU CSB-BP013571HU CSB-MP013571HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MCC Protein - abx164954 from Abbexa Category Protein Species Human, Mouse

MCC (transcript variant 2) - TP302890 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MCC Recombinant Protein Antigen - NBP1-85885PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MCC Recombinant Protein Antigen - NBP2-48671PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

MCC (88-103) - C33008 from Creative Peptides Category Peptide

MCC Peptide, Human - M34GP09301H from Creative Peptides Category Peptide Source Synthetic. Species Human

MCC (88 - 103) - AS-60204-1 from AnaSpec, Inc. Category Peptide Prices $99.00 Sizes 1 mg

MCC (88 - 103) - AS-60204-5 from AnaSpec, Inc. Category Peptide Prices $385.00 Sizes 5 mg

Colorectal mutant cancer protein (MCC), partial, Recombinant Protein - MBS950707 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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