| Gene Symbol |
MCC
|
| Entrez Gene |
4163
|
| Alt Symbol |
MCC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mutated in colorectal cancers
|
| Other Description |
colorectal mutant cancer protein
|
| Swissprots |
D3DT05 Q6ZR04 P23508
|
| Accessions |
EAW48984 EAW48985 EAW48986 EAW48987 P23508 AK096212 BAG53232 AK128596 BAC87521 AK300259 BAH13246 AL359558 AM393612 CAL38488 BC009279 AAH09279 BC018919 AAH18919 BC043431 BX537952 CAD97919 BX647710 CF887436 CR749713 EU831990 ACE87431 EU832083 ACE86745 M62397 AAA52069 XM_005271991 XP_005272048 NM_001085377 NP_001078846 NM_002387 NP_002378
|
| Function |
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440}.
|
| Subcellular Location |
Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
|
| Tissue Specificity |
Expressed in a variety of tissues.
|