WEE1

Gene Symbol WEE1
Entrez Gene 7465
Alt Symbol WEE1A, WEE1hu
Species Human
Gene Type protein-coding
Description WEE1 G2 checkpoint kinase
Other Description WEE1 homolog|WEE1+ homolog|wee1-like protein kinase|wee1A kinase
Swissprots B3KVE1 P30291 D3DQV0
Accessions CAC14173 EAW68586 EAW68587 EAW68588 P30291 AK122837 BAG53753 BC051831 AAH51831 BC070052 AAH70052 BQ024511 BX641032 CAE46020 EU832325 ACE87582 EU832410 ACE86895 U10564 AAB60401 X62048 CAA43979 XM_005253118 XP_005253175 XM_005253119 XP_005253176 NM_001143976 NP_001137448 NM_003390 NP_003381
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Subcellular Location Nucleus.
Top Pathways Cell cycle

Mouse/Human/Rat WEE1 ELISA Kit (Cell-Based ELISA) - LS-F2389 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human/Rat Phospho-WEE1 (Ser642) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1430 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

WEE1 Colorimetric Cell-Based ELISA Kit - CB5729 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

WEE1 (Phospho-Ser642) Colorimetric Cell-Based ELISA Kit - CBP1462 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

WEE1 homolog (S. pombe) , ELISA Kit - MBS9318404 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Wee1-like protein kinase, ELISA Kit - MBS282999 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WEE1 ELISA Kit - DEIA-XYA1829 from Creative Diagnostics

Category ELISA Kit

WEE1 (Phospho-Ser642) ELISA Kit - DEIA-XYA1830 from Creative Diagnostics

Category ELISA Kit

Human WEE1 ELISA Kit - E040576 from Biobool

Category ELISA Kit

anti-WEE1 antibody - ARG55245 from Arigo Biolaboratories

Category ELISA Kit

WEE1 Colorimetric Cell-Based ELISA Kit - EKA50626 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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