WEE1

Gene Symbol	WEE1
Entrez Gene	7465
Alt Symbol	WEE1A, WEE1hu
Species	Human
Gene Type	protein-coding
Description	WEE1 G2 checkpoint kinase
Other Description	WEE1 homolog|WEE1+ homolog|wee1-like protein kinase|wee1A kinase
Swissprots	B3KVE1 P30291 D3DQV0
Accessions	CAC14173 EAW68586 EAW68587 EAW68588 P30291 AK122837 BAG53753 BC051831 AAH51831 BC070052 AAH70052 BQ024511 BX641032 CAE46020 EU832325 ACE87582 EU832410 ACE86895 U10564 AAB60401 X62048 CAA43979 XM_005253118 XP_005253175 XM_005253119 XP_005253176 NM_001143976 NP_001137448 NM_003390 NP_003381
Function	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Subcellular Location	Nucleus.
Top Pathways	Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Wee1 full length protein - ab131844 from Abcam Category Protein Source Wheat germ Species Human

Human Wee1 protein fragment - ab125596 from Abcam Category Protein Source E. coli Species Human

WEE1 Antibody Blocking Peptide - LS-E6323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WEE1 Blocking Peptide - LS-E7330 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WEE1 Antibody Blocking Peptide - LS-E7329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WEE1 Antibody Blocking Peptide - LS-E9501 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WEE1 Antibody Blocking Peptide - LS-E9500 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Wee1 Protein - H00007465-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Wee1 Protein - H00007465-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Wee1 Recombinant Protein - P4796 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Wee1 Peptide - P1438 from Novus Biologicals Category Peptide Species Human

Wee1 Peptide - P1437 from Novus Biologicals Category Peptide Species Human

Wee1 Peptide - P3109 from Novus Biologicals Category Peptide Species Human

Wee1 Peptide - P3110 from Novus Biologicals Category Peptide Species Human

Phospho-Wee1S53-Antibody-Blocking-peptide - BP3285a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-Wee1S123-Antibody-Blocking-peptide - BP3284a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

WEE1-Antibody-Center-Blocking-Peptide - BP8106c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WEE1-Antibody-C-term-Blocking-Peptide - BP8106b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Wee1 Blocking Peptide - 33R-10639 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

Wee1 Blocking Peptide - 33R-10451 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

WEE1 / Wee1-like protein kinase - H00007465-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WEE1 / Wee1-like protein kinase - H00007465-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WEE1 / Wee1-like protein kinase - H00007465-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WEE1 / Wee1-like protein kinase - H00007465-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

WEE1 / Wee1-like protein kinase - P4796 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

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