WEE1

Gene Symbol	WEE1
Entrez Gene	7465
Alt Symbol	WEE1A, WEE1hu
Species	Human
Gene Type	protein-coding
Description	WEE1 G2 checkpoint kinase
Other Description	WEE1 homolog|WEE1+ homolog|wee1-like protein kinase|wee1A kinase
Swissprots	B3KVE1 P30291 D3DQV0
Accessions	CAC14173 EAW68586 EAW68587 EAW68588 P30291 AK122837 BAG53753 BC051831 AAH51831 BC070052 AAH70052 BQ024511 BX641032 CAE46020 EU832325 ACE87582 EU832410 ACE86895 U10564 AAB60401 X62048 CAA43979 XM_005253118 XP_005253175 XM_005253119 XP_005253176 NM_001143976 NP_001137448 NM_003390 NP_003381
Function	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Subcellular Location	Nucleus.
Top Pathways	Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Wee 1 CRISPR/Cas9 KO Plasmid (h) - sc-400701 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 HDR Plasmid (h) - sc-400701-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 Double Nickase Plasmid (h) - sc-400701-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 Double Nickase Plasmid (h2) - sc-400701-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 CRISPR Activation Plasmid (h) - sc-400701-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 CRISPR Activation Plasmid (h2) - sc-400701-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 Lentiviral Activation Particles (h) - sc-400701-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 Lentiviral Activation Particles (h2) - sc-400701-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 siRNA (h) - sc-36835 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Wee 1 shRNA Plasmid (h) - sc-36835-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Wee 1 shRNA (h) Lentiviral Particles - sc-36835-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Wee1 RNAi - H00007465-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU003621 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK2460 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2458 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2459 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1322 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1322 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00044 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00044

WEE1 siRNA (Human) - CRH5106 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

WEE1 - MBS8232272 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human WEE1 (NM_003390.3) - SHH446732 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human WEE1(NM_001143976.1) - SHL124770 from Creative biogene Category siRNA Species Reactivities Human

Wee 1 CRISPR/Cas9 KO Plasmid (h2) - sc-400701-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wee 1 HDR Plasmid (h2) - sc-400701-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

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