TNFRSF10B

Gene Symbol	TNFRSF10B
Entrez Gene	8795
Alt Symbol	CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 10b
Other Description	Fas-like protein|TNF receptor superfamily member 10b|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA damage-inducible cell death receptor(killer)|tumor necrosis factor receptor superfamily member 10B|tumor necrosis factor receptor-like protein ZTNFR9
Swissprots	O15508 O14720 O15517 O15531 Q6UXM8 O14763 Q7Z360 Q9BVE0
Accessions	ABK41895 ADU05473 BAA33723 BAB39708 CCA94572 EAW63640 EAW63641 EAW63642 EAW63643 O14763 AB451272 BAG70086 AB451399 BAG70213 AF012535 AAB67103 AF012628 AAB67109 AF016266 AAB81180 AF016268 AAC01565 AF016849 AAC51778 AF018657 AAB70577 AF018658 AAB70578 AF020501 AAB71412 AF022386 AAB71949 AF153687 AAF75587 AF192548 AAF07175 AK291216 BAF83905 AK296128 BAH12263 AK298602 BAH12824 AL529460 AY358277 AAQ88644 BC001281 AAH01281 BC043400 BX537617 CAD97801 BX538104 CAD98017 BX538179 CAD98053 CR541898 CAG46696 CX870630 DA738472 DA889488 FJ200482 ACO54879 HG500966 XR_949500 NM_003842 NP_003833 NM_147187 NP_671716 NR_027140
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, p53 signaling pathway, Natural killer cell mediated cytotoxicity, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD262 (TRAIL R2) Human ELISA Kit - ab113340 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 2 pg/ml Range 2.46 pg/ml - 600 pg/ml

DR5 (CD262) Human ELISA Kit - ab46013 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 6 pg/ml Range 31.25 pg/ml - 1000 pg/ml

Human TRAIL R2 ELISA Kit - RAB0481 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human TNFRSF10B / Killer / DR5 ELISA Kit (Sandwich ELISA) - LS-F200 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.458 pg/ml Range 2.458-240 pg/ml

Human TNFRSF10B / Killer / DR5 ELISA Kit (Sandwich ELISA) - LS-F12842 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.31 Range 2.458-240 pg/ml

Tumor necrosis factor receptor superfamily member 10B, TNFRSF10B, Human, ELISA Kit - E8953h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.31-20.0 ng/mL

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2 (TRAIL-R2/DR5), Human, ELISA Kit - CSB-E13164h from ARP American Research Products Category ELISA Kit Prices $450.00, $595.00, $596.00, $599.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TNFRSF10B (Human) IP-WB Antibody Pair - H00008795-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TNFRSF10B (Human) Matched Antibody Pair - H00008795-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human TRAIL R2 ELISA - ELH-TRAILR2 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 2 pg/ml Range 2 pg/ml - 600 pg/ml

Human Trail R2/DR5 ELISA KIT - DEIA9591 from Creative Diagnostics Category ELISA Kit Sensitivity 6 pg/mL

TRAIL R2, ELISA Kit - MBS335487 from MyBioSource Category ELISA Kit Prices $305.00, $470.00, $675.00 Sizes 1x48 wells (Pre-Coated), 1x96 wells (Pre-Coated), 2x96 wells (Pre-Coated) Sensitivity The sensitivity, minimum detectable dose of human TRAIL R2 using this TRAIL R2 ELISA kit was found to be <6pg/ml. This was determined by adding 3 standard deviations to the mean OD obtained when the zero standard was assayed 32 times.

tumor necrosis factor receptor superfamily, member 10b, ELISA Kit - MBS704972 from MyBioSource Category ELISA Kit Prices $250.00, $435.00, $625.00, $2,595.00, $4,905.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 10B (TNFRSF10B), ELISA Kit - MBS2025002 from MyBioSource Category ELISA Kit Prices $370.00, $550.00, $750.00, $3,065.00, $5,550.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.062ng/mL. Range 0.156-10ng/mL

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS102666 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS087312 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS105924 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS051397 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS087768 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS062693 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10B (TNFRSF10B) - SEA818Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2(TRAIL-R2/DR5) ELISA Kit - CSB-E13164h from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

Mouse TNFRSF10B / Killer / DR5 ELISA Kit (Custom ELISA) - LS-F20258 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 2.458-240 pg/ml

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS052507 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Necrosis Factor Receptor Superfamily, Member 17, ELISA Kit - MBS076349 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more