TNFRSF10B

Gene Symbol	TNFRSF10B
Entrez Gene	8795
Alt Symbol	CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 10b
Other Description	Fas-like protein|TNF receptor superfamily member 10b|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA damage-inducible cell death receptor(killer)|tumor necrosis factor receptor superfamily member 10B|tumor necrosis factor receptor-like protein ZTNFR9
Swissprots	O15508 O14720 O15517 O15531 Q6UXM8 O14763 Q7Z360 Q9BVE0
Accessions	ABK41895 ADU05473 BAA33723 BAB39708 CCA94572 EAW63640 EAW63641 EAW63642 EAW63643 O14763 AB451272 BAG70086 AB451399 BAG70213 AF012535 AAB67103 AF012628 AAB67109 AF016266 AAB81180 AF016268 AAC01565 AF016849 AAC51778 AF018657 AAB70577 AF018658 AAB70578 AF020501 AAB71412 AF022386 AAB71949 AF153687 AAF75587 AF192548 AAF07175 AK291216 BAF83905 AK296128 BAH12263 AK298602 BAH12824 AL529460 AY358277 AAQ88644 BC001281 AAH01281 BC043400 BX537617 CAD97801 BX538104 CAD98017 BX538179 CAD98053 CR541898 CAG46696 CX870630 DA738472 DA889488 FJ200482 ACO54879 HG500966 XR_949500 NM_003842 NP_003833 NM_147187 NP_671716 NR_027140
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, p53 signaling pathway, Natural killer cell mediated cytotoxicity, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DR5 protein fragment - ab157268 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

DR5 protein (Fc Chimera Active) - ab83547 from Abcam Category Protein Prices $315.00 Sizes 25 µg Source HEK 293 cells Species Human

Active human DR5 protein fragment - ab174009 from Abcam Category Protein Prices $372.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human DR5 protein fragment - ab109149 from Abcam Category Protein Prices $410.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human DR5 protein fragment - ab55763 from Abcam Category Protein Prices $315.00 Sizes 50 µg Source E. coli Species Human

Active human DR5 protein fragment - ab111467 from Abcam Category Protein Prices $315.00 Sizes 50 µg Source E. coli Species Human

Human DR5 peptide - ab8449 from Abcam Category Peptide Species Human

Human DR5 peptide - ab41765 from Abcam Category Peptide Species Human

Human DR5 peptide - ab95918 from Abcam Category Peptide

Human DR5 protein fragment - ab56519 from Abcam Category Protein Source HEK 293 cells Species Human

Human DR5 protein fragment - ab199801 from Abcam Category Protein Source E. coli Species Human

Human DR5 protein fragment - ab185413 from Abcam Category Protein Source E. coli Species Human

Human DR5 protein fragment - ab109157 from Abcam Category Protein Source HEK 293 cells Species Human

Human sTRAIL Receptor 2 protein fragment - ab151385 from Abcam Category Protein Source HEK 293 cells Species Human

sTRAIL Receptor 2 full length protein - ab643 from Abcam Category Protein Source E. coli

TNFRSF10B / Killer / DR5 Antibody Blocking Peptide - LS-E10618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF10B / Killer / DR5 Antibody Blocking Peptide - LS-E29870 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TRAIL R2/TNFRSF10B Protein - NBP2-35030 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,299.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

TRAIL R2/TNFRSF10B Partial Recombinant Protein - H00008795-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRAIL R2/TNFRSF10B Recombinant Protein - P4092 from Novus Biologicals Category Protein Prices $549.00 Sizes 50 µg Species Human

TRAIL R2/TNFRSF10B Peptide - NBP1-76986PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Recombinant Human TRAIL R2/TNFRSF10B Protein - NBP1-99444 from Novus Biologicals Category Protein Prices $195.00 Sizes 50 µg Source E. coli Species Human

TRAIL R2/TNFRSF10B Recombinant Protein - H00008795-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

TRAIL R2/TNFRSF10B Recombinant Protein - P5032 from Novus Biologicals Category Protein Prices $799.00 Sizes 50 µg Species Human

Soluble TRAIL Receptor-2 Recombinant Protein (Active) - GTX48105-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

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