| Gene Symbol |
TNFRSF10B
|
| Entrez Gene |
8795
|
| Alt Symbol |
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor receptor superfamily, member 10b
|
| Other Description |
Fas-like protein|TNF receptor superfamily member 10b|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA damage-inducible cell death receptor(killer)|tumor necrosis factor receptor superfamily member 10B|tumor necrosis factor receptor-like protein ZTNFR9
|
| Swissprots |
O15508 O14720 O15517 O15531 Q6UXM8 O14763 Q7Z360 Q9BVE0
|
| Accessions |
ABK41895 ADU05473 BAA33723 BAB39708 CCA94572 EAW63640 EAW63641 EAW63642 EAW63643 O14763 AB451272 BAG70086 AB451399 BAG70213 AF012535 AAB67103 AF012628 AAB67109 AF016266 AAB81180 AF016268 AAC01565 AF016849 AAC51778 AF018657 AAB70577 AF018658 AAB70578 AF020501 AAB71412 AF022386 AAB71949 AF153687 AAF75587 AF192548 AAF07175 AK291216 BAF83905 AK296128 BAH12263 AK298602 BAH12824 AL529460 AY358277 AAQ88644 BC001281 AAH01281 BC043400 BX537617 CAD97801 BX538104 CAD98017 BX538179 CAD98053 CR541898 CAG46696 CX870630 DA738472 DA889488 FJ200482 ACO54879 HG500966 XR_949500 NM_003842 NP_003833 NM_147187 NP_671716 NR_027140
|
| Function |
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Apoptosis, p53 signaling pathway, Natural killer cell mediated cytotoxicity, Measles
|
![Overlay histogram showing HeLa cells stained with ab166650 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab166650, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_2/10155_ab166650-1-ab166650FC.jpg)
![All lanes : Anti-DR5 antibody [EPR1659(2)] (ab181846) at 1/50000 dilutionLane 1 : HepG2 cell lysateLane 2 : HeLa cell lysateLane 3 : HT1080 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_2/10156_ab181846-212830-ab181846-wb.jpg)
![All lanes : Anti-sTRAIL Receptor 2 antibody [7F4-F8-G11] (ab176469) at 1/500 dilutionLane 1 : Mouse kindey cell lysateLane 2 : Mouse brain cell lysateLane 3 : HCT116 cell lysateLane 4 : HeLa cell lysate](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_5/6463_ab176469-203908-ab1764691.jpg)
