TNFRSF10B

Gene Symbol	TNFRSF10B
Entrez Gene	8795
Alt Symbol	CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 10b
Other Description	Fas-like protein|TNF receptor superfamily member 10b|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|death receptor 5|p53-regulated DNA damage-inducible cell death receptor(killer)|tumor necrosis factor receptor superfamily member 10B|tumor necrosis factor receptor-like protein ZTNFR9
Swissprots	O15508 O14720 O15517 O15531 Q6UXM8 O14763 Q7Z360 Q9BVE0
Accessions	ABK41895 ADU05473 BAA33723 BAB39708 CCA94572 EAW63640 EAW63641 EAW63642 EAW63643 O14763 AB451272 BAG70086 AB451399 BAG70213 AF012535 AAB67103 AF012628 AAB67109 AF016266 AAB81180 AF016268 AAC01565 AF016849 AAC51778 AF018657 AAB70577 AF018658 AAB70578 AF020501 AAB71412 AF022386 AAB71949 AF153687 AAF75587 AF192548 AAF07175 AK291216 BAF83905 AK296128 BAH12263 AK298602 BAH12824 AL529460 AY358277 AAQ88644 BC001281 AAH01281 BC043400 BX537617 CAD97801 BX538104 CAD98017 BX538179 CAD98053 CR541898 CAG46696 CX870630 DA738472 DA889488 FJ200482 ACO54879 HG500966 XR_949500 NM_003842 NP_003833 NM_147187 NP_671716 NR_027140
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, p53 signaling pathway, Natural killer cell mediated cytotoxicity, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD262 / TRAILR2 - H00008795-T01 from Acris Antibodies Prices $320.00 Sizes 100 µl

TNFRSF10B overexpression lysate - LY407781 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TNFRSF10B 293 Cell Lysate - 404371 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

TNFRSF10B 293 Cell Lysate - 401160 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

TRAIL R2/TNFRSF10B Overexpression Lysate (Denatured) - H00008795-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TRAIL R2/TNFRSF10B Overexpression Lysate (Native) - NBL1-17142 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TRAIL R2/TNFRSF10B Overexpression Lysate (Native) - NBP2-05437 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DR5 (h): 293 Lysate - sc-110563 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TNFRSF10B Over-expression Lysate Product - GWB-DEEF29 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

TNFRSF10B Over-expression Lysate Product - GWB-C2C399 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human TRAIL R2 / CD262 / TNFRSF10B HEK293 Cell Lysate (WB positive control) - 10465-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TRAIL R2 / CD262 / TNFRSF10B HEK293 Cell Lysate (WB positive control) - 10465-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TNFRSF10B Human Cells Transfected Lysate (positive control) (denatured) - orb173028 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

TRAIL R2/TNFRSF10B Overexpression Lysate (Denatured) - H00008795-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human TNFRSF10B Human Cells Transfected Lysate (positive control) (denatured) - orb173220 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

TNFRSF10B-knockout Cell lysate - LC810276 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human TNFRSF10B Knockdown Stable Cell Line - CSC-DC016351 from Creative biogene Category Cell Line Species Human

Human TNFRSF10B Knockout Cell Line-HeLa - CSC-RT0571 from Creative biogene Category Cell Line Species Human

TNFRSF10B KO Cell Lysate-HeLa - CLKO-0076 from Creative biogene Category Cell Lysate

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