MAP4K1

Gene Symbol MAP4K1
Entrez Gene 11184
Alt Symbol HPK1
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase kinase 1
Other Description MAPK/ERK kinase kinase kinase 1|MEK kinase kinase 1|MEKKK 1|hematopoietic progenitor kinase 1
Swissprots Q92918
Accessions EAW56799 EAW56800 EAW56801 EAW56802 Q92918 AA995240 AK303267 BAG64349 AW137524 BC148359 AAI48360 BC152994 AAI52995 BX345201 HY074876 U66464 AAB97983 XM_011526403 XP_011524705 XM_011526404 XP_011524706 NM_001042600 NP_001036065 NM_007181 NP_009112
Function Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. {ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}.
Tissue Specificity Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.
Top Pathways MAPK signaling pathway

HPK1 Antibody - 4472 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from WEHI231 cells, untreated or treated with staurosporine to induce HPK1 cleavage, using HPK1 Antibody.

HPK1 (C-9) - sc-376169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HPK1 (C-9): sc-376169. Western blot analysis of HPK1 expression in Ramos whole cell lysate.

HPK1 (G-8) - sc-376103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HPK1 (G-8): sc-376103. Western blot analysis of HPK1 expression in BJAB whole cell lysate.

HPK1 (H-200) - sc-25414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HPK1 (H-200): sc-25414. Western blot analysis of HPK1 expression in Ramos whole cell lysate.

HPK1 (G-9) - sc-374183 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HPK1 (G-9): sc-374183. Western blot analysis of HPK1 expression in BJAB whole cell lysate.

HPK1 (N-19) - sc-6231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HPK1 (N-19): sc-6231. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil showing cytoplasmic localization.

HPK1 (C-20) - sc-6230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HPK1 (C-20): sc-6230. Western blot analysis of HPK1 expression in BJAB whole cell lysate.

Anti-MAP4K1 antibody - ab75940 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAP4K1 antibody (ab75940) at 1/50 dilution + Jurkat cell line lysates at 35 µg

Anti-MAP4K1 antibody - ab137287 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAP4K1 antibody (ab137287) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-MAP4K1 antibody - ab2646 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MAP4K1 antibody [2A1] - ab127925 from Abcam

Prices $407.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 2A1
ab127925, at 1/200 dilution, staining MAP4K1 in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

Anti-MAP4K1 antibody [EP630Y] - ab33910 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP630Y
Immunohistochemical analysis of paraffin-embedded human lymph node using anti-HPK1

Anti-MAP4K1 / HPK1 Antibody (clone 2A1) IHC-plus™ - LS-B6261 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 2A1
Anti-MAP4K1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6261 dilution 1:200.

Anti-MAP4K1 / HPK1 Antibody (aa2-14) IHC-plus™ - LS-B6447 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MAP4K1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6447 concentration 2.5 ug/ml.

Anti-MAP4K1 / HPK1 Antibody (phospho-Ser171) - LS-C96788 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-MAP4K1-pS171 Phospho-specific antibody (RB12751) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-MAP4K1 / HPK1 Antibody (phospho-Thr165) - LS-C96786 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-MAP4K1-pT165 Phospho-specific antibody (RB12715) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-MAP4K1 / HPK1 Antibody (phospho-Y381) - LS-C158635 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-MAP4K1-pY381 Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-MAP4K1 / HPK1 Antibody (phospho-Tyr381, AP) - LS-C262585 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP4K1 / HPK1 Antibody (phospho-Tyr381, APC) - LS-C262588 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP4K1 / HPK1 Antibody (aa348-397) - LS-C200202 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HUVEC cells using MEKKK 1 antibody.

Anti-MAP4K1 / HPK1 Antibody (phospho-Tyr381, FITC) - LS-C262590 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP4K1 / HPK1 Antibody (phospho-Tyr381, Biotin) - LS-C262589 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP4K1 / HPK1 Antibody (phospho-Tyr381, Azide-free, HRP) - LS-C262591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP4K1 / HPK1 Antibody (Leu397) - LS-C176829 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of HPK1 (L397) pAb in extracts from HepG2 cells.

Anti-MAP4K1 / HPK1 Antibody (aa218-267) - LS-C80801 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.
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