MAP4K1

Gene Symbol	MAP4K1
Entrez Gene	11184
Alt Symbol	HPK1
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase kinase 1
Other Description	MAPK/ERK kinase kinase kinase 1|MEK kinase kinase 1|MEKKK 1|hematopoietic progenitor kinase 1
Swissprots	Q92918
Accessions	EAW56799 EAW56800 EAW56801 EAW56802 Q92918 AA995240 AK303267 BAG64349 AW137524 BC148359 AAI48360 BC152994 AAI52995 BX345201 HY074876 U66464 AAB97983 XM_011526403 XP_011524705 XM_011526404 XP_011524706 NM_001042600 NP_001036065 NM_007181 NP_009112
Function	Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. {ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}.
Tissue Specificity	Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HPK1 CRISPR/Cas9 KO Plasmid (h) - sc-402367 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 HDR Plasmid (h) - sc-402367-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 Double Nickase Plasmid (h) - sc-402367-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 Double Nickase Plasmid (h2) - sc-402367-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 CRISPR Activation Plasmid (h) - sc-402367-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 CRISPR Activation Plasmid (h2) - sc-402367-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 Lentiviral Activation Particles (h) - sc-402367-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 Lentiviral Activation Particles (h2) - sc-402367-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HPK1 siRNA (h) - sc-35591 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HPK1 shRNA Plasmid (h) - sc-35591-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HPK1 shRNA (h) Lentiviral Particles - sc-35591-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MAP4K1 RNAi - H00011184-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU005191 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1167 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1166 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1165 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1169 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1168 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1170 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12999 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12999 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01266 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01266

MAP4K1 siRNA (Human) - CRH7664 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MAP4K1 (NM_007181.4) - SHH337799 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAP4K1(NM_001042600.1) - SHH174683 from Creative biogene Category siRNA Species Reactivities Human

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