| Gene Symbol |
MAP4K1
|
| Entrez Gene |
11184
|
| Alt Symbol |
HPK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase kinase 1
|
| Other Description |
MAPK/ERK kinase kinase kinase 1|MEK kinase kinase 1|MEKKK 1|hematopoietic progenitor kinase 1
|
| Swissprots |
Q92918
|
| Accessions |
EAW56799 EAW56800 EAW56801 EAW56802 Q92918 AA995240 AK303267 BAG64349 AW137524 BC148359 AAI48360 BC152994 AAI52995 BX345201 HY074876 U66464 AAB97983 XM_011526403 XP_011524705 XM_011526404 XP_011524706 NM_001042600 NP_001036065 NM_007181 NP_009112
|
| Function |
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. {ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}.
|
| Tissue Specificity |
Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.
|
| Top Pathways |
MAPK signaling pathway
|
![Western Blot: MAP4K1 Overexpression Lysate (Adult Normal) [NBP2-07520] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAP4K1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15214_MAP4K1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-07520-img0001.jpg)