| Gene Symbol |
SLC1A3
|
| Entrez Gene |
6507
|
| Alt Symbol |
EA6, EAAT1, GLAST, GLAST1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 1 (glial high affinity glutamate transporter), member 3
|
| Other Description |
GLAST-1|excitatory amino acid transporter 1|sodium-dependent glutamate/aspartate transporter 1|solute carrier family 1 member 3
|
| Swissprots |
B2R5T3 Q4JCQ8 P43003
|
| Accessions |
AEZ00566 AEZ00567 CAA83507 EAW55945 EAW55946 P43003 AF070609 AK057823 AK293886 BAG57275 AK295032 BAG58087 AK295754 BAG58584 AK312304 BAG35230 AY954110 AAY28724 BC022285 BC037310 AAH37310 BC054475 AAH54475 BQ019197 D26443 BAA05462 DC320625 L19158 U03504 AAA50428 XM_005248342 XP_005248399 XM_011514084 XP_011512386 NM_001166695 NP_001160167 NM_001166696 NP_001160168 NM_001289939 NP_001276868 NM_001289940 NP_001276869 NM_004172 NP_004163
|
| Function |
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
|
| Top Pathways |
Glutamatergic synapse
|