SLC1A3

Gene Symbol SLC1A3
Entrez Gene 6507
Alt Symbol EA6, EAAT1, GLAST, GLAST1
Species Human
Gene Type protein-coding
Description solute carrier family 1 (glial high affinity glutamate transporter), member 3
Other Description GLAST-1|excitatory amino acid transporter 1|sodium-dependent glutamate/aspartate transporter 1|solute carrier family 1 member 3
Swissprots B2R5T3 Q4JCQ8 P43003
Accessions AEZ00566 AEZ00567 CAA83507 EAW55945 EAW55946 P43003 AF070609 AK057823 AK293886 BAG57275 AK295032 BAG58087 AK295754 BAG58584 AK312304 BAG35230 AY954110 AAY28724 BC022285 BC037310 AAH37310 BC054475 AAH54475 BQ019197 D26443 BAA05462 DC320625 L19158 U03504 AAA50428 XM_005248342 XP_005248399 XM_011514084 XP_011512386 NM_001166695 NP_001160167 NM_001166696 NP_001160168 NM_001289939 NP_001276868 NM_001289940 NP_001276869 NM_004172 NP_004163
Function Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
Top Pathways Glutamatergic synapse

EAAT1 (D44E2) XP ® Rabbit mAb - 5684 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D44E2
Western blot analysis of extracts of tissue from mouse brain, rat brain, and human cerebellum using EAAT1 (D44E2) XP ® Rabbit mAb.

EAAT1 Antibody - 4166 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human cerebellum, mouse and rat brain using EAAT1 Antibody.

EAAT1 (D20D5) Rabbit mAb - 5685 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D20D5
Western blot analysis of extracts from mouse and rat brain using EAAT1 (D20D5) Rabbit mAb.

EAAT1 (H-50) - sc-15316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EAAT1 (H-50): sc-15316. Western blot analysis of EAAT1 expression in EOC 20 whole cell lysate.

EAAT1 (C-19) - sc-7757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EAAT1 Antibody (C-19): sc-7757. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing membrane staining of Purkinje cells and neuropil staining in granular and molecular layers.

EAAT1 (N-19) - sc-7758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EAAT1 (N-19): sc-7758. Western blot analysis of EAAT1 expression in rat whole brain (A) and cerebellum (B) tissue extracts.

Anti-EAAT1 antibody - ab416 from Abcam

Prices $401.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab416 staining zebrafish retina sections by IHC-Fr. The tissue was fixed with paraformaldehyde and an antigen retrieval step was performed with sodium citrate pH 6. Blocking of the sample was done with 5%BSA in PBS containing 01% Tween 20 and 0.5% Triton X, for 60 minutes at 23°C, followed by staining with ab416 at 1/100 in blocking solution for 16h at 4°C. An alexa 488 conjugated goat anti-rabbit polyclonal antibody at 1/1000 was used as the secondary antibody. Nuclei are stained in blue with DAPI. EAAT1 expression can be observed in the inner plexiform layer (in green).See Abreview

Anti-EAAT1 antibody - ab41751 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EAAT1 antibody (ab41751) at 1 µg/ml + Brain (Human) Tissue Lysate - adult normal tissue (ab29466) at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-EAAT1 antibody - ab166937 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-EAAT1 antibody (ab166937) at 2 µg/ml + Human Brain (Hippocampus) lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-EAAT1 antibody [10D4] - ab49643 from Abcam

Host Mouse
Clonality Monoclonal
Clone 10D4

Anti-EAAT1 antibody [2G7c2] - ab181661 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G7c2

Anti-EAAT1 antibody [EPR12685] - N-terminal - ab176557 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12685
All lanes : Anti-EAAT1 antibody [EPR12685] - N-terminal (ab176557) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : Human cerebellum lysateLysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-EAAT1 antibody [EPR12686] - ab181036 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12686
ab181036 staining EAAT1 in monkey brain tissue sections by Immunohistochemistry (PFA perfusion fixed frozen sections). Tissue samples were fixed by perfusion with paraformaldehyde, blocked with 10% serum at 24°C and antigen retrieval was by heat mediation in 10mM citrate acid + 0.05% Tween 20. The sample was incubated with primary antibody (1/100 in 2% donkey buffer) at 24°C for 13 hours. An Alexa Fluor® 647-conjugated donkey anti-rabbit polyclonal (1/100) was used as the secondary antibody.See Abreview

Anti-EAAT1 antibody - C-terminal - ab167000 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EAAT1 antibody - C-terminal (ab167000) at 1/500 dilution + PC-EAAT1 sample

Anti-EAAT1 antibody - Cytoplasmic domain - ab140946 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cerebellum (molecular layer and Purkinje layer) labelling EAAT1 with ab140946 at 2.5µg/ml.

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus) - LS-C15436 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC1A3 / EAAT1 Antibody (aa161-177) - LS-C15447 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus) - LS-C66665 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus) - LS-C94136 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC1A3 / EAAT1 Antibody (aa516-531) - LS-C129304 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus) - LS-C129305 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus, clone 2G7c2) - LS-C144561 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G7c2

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus) - LS-C144600 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus, clone 2G7c2) - LS-C153303 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G7c2

Anti-SLC1A3 / EAAT1 Antibody (C-Terminus, Magnetic beads) - LS-C171741 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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