| Gene Symbol |
RIT1
|
| Entrez Gene |
6016
|
| Alt Symbol |
NS8, RIBB, RIT, ROC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras-like without CAAX 1
|
| Other Description |
GTP-binding protein Rit1|GTP-binding protein Roc1|Ric-like, expressed in many tissues|ras-like protein expressed in many tissues|ras-like without CAAX protein 1
|
| Swissprots |
Q5VY90 Q5VY89 B4DQE8 O00720 O00646 Q92963
|
| Accessions |
EAW53024 Q92963 AF084462 AAD13021 AF493923 AAM12637 AK298768 BAG60910 AK314239 BAG36908 BC104186 AAI04187 BC104187 AAI04188 BI916790 BM546985 BQ918446 BU674989 CR407639 CAG28567 U71203 AAB42213 U78165 AAB64246 Y07566 CAA68851 NM_001256820 NP_001243749 NM_001256821 NP_001243750 NM_006912 NP_008843
|
| Function |
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}.
|
| Subcellular Location |
Cell membrane.
|
| Tissue Specificity |
Expressed in many tissues.
|