Gene Symbol | RIT1 |
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Entrez Gene | 6016 |
Alt Symbol | NS8, RIBB, RIT, ROC1 |
Species | Human |
Gene Type | protein-coding |
Description | Ras-like without CAAX 1 |
Other Description | GTP-binding protein Rit1|GTP-binding protein Roc1|Ric-like, expressed in many tissues|ras-like protein expressed in many tissues|ras-like without CAAX protein 1 |
Swissprots | Q5VY90 Q5VY89 B4DQE8 O00720 O00646 Q92963 |
Accessions | EAW53024 Q92963 AF084462 AAD13021 AF493923 AAM12637 AK298768 BAG60910 AK314239 BAG36908 BC104186 AAI04187 BC104187 AAI04188 BI916790 BM546985 BQ918446 BU674989 CR407639 CAG28567 U71203 AAB42213 U78165 AAB64246 Y07566 CAA68851 NM_001256820 NP_001243749 NM_001256821 NP_001243750 NM_006912 NP_008843 |
Function | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}. |
Subcellular Location | Cell membrane. |
Tissue Specificity | Expressed in many tissues. |
Rit CRISPR/Cas9 KO Plasmid (h) - sc-405355 from Santa Cruz Biotechnology
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Rit HDR Plasmid (h) - sc-405355-HDR from Santa Cruz Biotechnology
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Rit Double Nickase Plasmid (h) - sc-405355-NIC from Santa Cruz Biotechnology
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Rit Double Nickase Plasmid (h2) - sc-405355-NIC-2 from Santa Cruz Biotechnology
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Rit CRISPR Activation Plasmid (h) - sc-405355-ACT from Santa Cruz Biotechnology
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Rit CRISPR Activation Plasmid (h2) - sc-405355-ACT-2 from Santa Cruz Biotechnology
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Rit Lentiviral Activation Particles (h) - sc-405355-LAC from Santa Cruz Biotechnology
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Rit Lentiviral Activation Particles (h2) - sc-405355-LAC-2 from Santa Cruz Biotechnology
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Rit siRNA (h) - sc-106512 from Santa Cruz Biotechnology
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Rit shRNA Plasmid (h) - sc-106512-SH from Santa Cruz Biotechnology
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Rit shRNA (h) Lentiviral Particles - sc-106512-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU049501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18302 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18302 from Sigma-Aldrich
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RIT1 siRNA (Human) - CRH4082 from Cohesion Biosciences
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RIT1 - MBS8227302 from MyBioSource
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shRNA set against Human RIT1 (NM_006912.5) - SHH396072 from Creative biogene
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Human RIT1 siRNA - orb264584 from Biorbyt
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RIT1 shRNA Plasmid (Human) - CHH4082 from Cohesion Biosciences
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RIT1 miRNA 3'UTR clone - MiUTR4H-TG07534 from Creative biogene
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