EXOSC4

Gene Symbol	EXOSC4
Entrez Gene	54512
Alt Symbol	RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
Species	Human
Gene Type	protein-coding
Description	exosome component 4
Other Description	exosome complex component RRP41|exosome complex exonuclease RRP41|exosome component Rrp41|ribosomal RNA-processing protein 41
Swissprots	Q9NPD3
Accessions	EAW82166 Q9NPD3 AF281133 AAF82134 AK000598 BAA91279 BC002777 AAH02777 BM839994 JF432617 ADZ15834 XM_011517133 XP_011515435 XM_011517134 XP_011515436 NM_019037 NP_061910
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EXOSC4-Over-expression-Lysate - LY14430a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

EXOSC4 overexpression lysate - LY412805 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

EXOSC4 293 Cell Lysate - 406246 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Exosome component 4 Overexpression Lysate (Native) - NBL1-10386 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

EXOSC4 Over-expression Lysate Product - GWB-831D0A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human EXOSC4 Knockdown Stable Cell Line - CSC-DC005144 from Creative biogene Category Cell Line Species Human

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