EXOSC4

Gene Symbol EXOSC4
Entrez Gene 54512
Alt Symbol RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
Species Human
Gene Type protein-coding
Description exosome component 4
Other Description exosome complex component RRP41|exosome complex exonuclease RRP41|exosome component Rrp41|ribosomal RNA-processing protein 41
Swissprots Q9NPD3
Accessions EAW82166 Q9NPD3 AF281133 AAF82134 AK000598 BAA91279 BC002777 AAH02777 BM839994 JF432617 ADZ15834 XM_011517133 XP_011515435 XM_011517134 XP_011515436 NM_019037 NP_061910
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}.
Top Pathways RNA degradation

EXOSC4 (G-9) - sc-166772 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EXOSC4 (G-9): sc-166772. Western blot analysis of EXOSC4 expression in HeLa whole cell lysate.

EXOSC4 (C-16) - sc-87108 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EXOSC4 (C-16): sc-87108. Western blot analysis of EXOSC4 expression in BJAB nuclear extract.

EXOSC4 (H-245) - sc-98777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 antibody - ab130682 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EXOSC4 antibody (ab130682) at 1/100 dilution + U251 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-EXOSC4 / RRP41 Antibody (aa69-96, AP) - LS-C256881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa69-96, APC) - LS-C256882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa69-96, Azide-free, HRP) - LS-C256885 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa69-96, Biotin) - LS-C256883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa69-96, PE) - LS-C256886 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa69-96, FITC) - LS-C256884 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa1-50) - LS-C290427 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa50-100) - LS-C290428 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (aa69-96) - LS-C159578 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
EXOSC4 Antibody western blot of U251 cell line lysates (35 ug/lane). The EXOSC4 antibody detected the EXOSC4 protein (arrow).

Anti-EXOSC4 / RRP41 Antibody (aa1-101) - LS-C307940 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EXOSC4 / RRP41 Antibody (aa68-97) - LS-C321227 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC4 / RRP41 Antibody (N-Terminus) - LS-C30654 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
EXOSC4 antibody LS-C30654 was used in IHC to stain formalin-fixed, paraffin-embedded human liver.

Exosome component 4 Antibody - NBP1-57180 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exosome component 4 Antibody [NBP1-57180] - Jurkat cell lysate, Antibody Titration: 5.0ug/ml

Exosome component 4 Antibody - NBP1-82170 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Exosome component 4 Antibody [NBP1-82170] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Exosome component 4 Antibody (4F9) - H00054512-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F9
Western Blot: Exosome component 4 Antibody (4F9) [H00054512-M02] - Analysis of EXOSC4 expression in transfected 293T cell line by EXOSC4 monoclonal antibody (M02), clone 4F9.Lane 1: EXOSC4 transfected lysate(26.4 KDa).Lane 2: Non-transfected lysate.

Exosome component 4 Antibody (4F10) - H00054512-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F10
Western Blot: Exosome component 4 Antibody (4F10) [H00054512-M01] - Analysis of EXOSC4 expression in transfected 293T cell line by EXOSC4 monoclonal antibody (M01), clone 4F10.Lane 1: EXOSC4 transfected lysate(26.4 KDa).Lane 2: Non-transfected lysate.

Exosome component 4 Antibody - H00054512-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Monoclonal Anti-EXOSC4, (N-terminal) antibody produced in mouse - SAB1402591 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F10
<B>Immunoblotting</B><BR/>Monoclonal Anti-EXOSC4, antibody produced in mouse, clone 4F10, purified immunoglobulin: <B>Cat. No. SAB1402591</B>: Antibody concentration: 1 μg/mL. Specific band of ~37 kDa using immunogen protein lysate.

Monoclonal Anti-EXOSC4, (N-terminal) antibody produced in mouse - SAB1405127 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F9
<B>Immunoblotting</B><BR/>Monoclonal Anti-EXOSC4: <B>Cat. No. SAB1405127</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Anti-EXOSC4 antibody produced in rabbit - SAB4200397 from Sigma-Aldrich

Prices $343.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>HeLa cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton<SUP>™</SUP> X-100. Fixed cells were stained with 5 μg/mL Rabbit Anti-EXOSC4 (<B>Cat. No. SAB4200397</B>). The antibody was developed using Goat Anti-Rabbit IgG, Atto-488 conjugate (<B>Cat. No. 18772</B>).

Anti-EXOSC4 antibody produced in rabbit - AV40935 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EXOSC4: <B>Cat. No. AV40935</B>: Immunohistochemistry of EXOSC4 in Human Liver tissue with EXOSC4 antibody at 4-8 μg/mL.
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