EXOSC4
| Gene Symbol | EXOSC4 |
|---|---|
| Entrez Gene | 54512 |
| Alt Symbol | RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A |
| Species | Human |
| Gene Type | protein-coding |
| Description | exosome component 4 |
| Other Description | exosome complex component RRP41|exosome complex exonuclease RRP41|exosome component Rrp41|ribosomal RNA-processing protein 41 |
| Swissprots | Q9NPD3 |
| Accessions | EAW82166 Q9NPD3 AF281133 AAF82134 AK000598 BAA91279 BC002777 AAH02777 BM839994 JF432617 ADZ15834 XM_011517133 XP_011515435 XM_011517134 XP_011515436 NM_019037 NP_061910 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. |
| Top Pathways | RNA degradation |
EXOSC4 CRISPR/Cas9 KO Plasmid (h) - sc-405751 from Santa Cruz Biotechnology
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EXOSC4 HDR Plasmid (h) - sc-405751-HDR from Santa Cruz Biotechnology
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EXOSC4 Double Nickase Plasmid (h) - sc-405751-NIC from Santa Cruz Biotechnology
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EXOSC4 Double Nickase Plasmid (h2) - sc-405751-NIC-2 from Santa Cruz Biotechnology
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EXOSC4 CRISPR Activation Plasmid (h) - sc-405751-ACT from Santa Cruz Biotechnology
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EXOSC4 CRISPR Activation Plasmid (h2) - sc-405751-ACT-2 from Santa Cruz Biotechnology
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EXOSC4 Lentiviral Activation Particles (h) - sc-405751-LAC from Santa Cruz Biotechnology
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EXOSC4 Lentiviral Activation Particles (h2) - sc-405751-LAC-2 from Santa Cruz Biotechnology
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EXOSC4 siRNA (h) - sc-77781 from Santa Cruz Biotechnology
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EXOSC4 shRNA Plasmid (h) - sc-77781-SH from Santa Cruz Biotechnology
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EXOSC4 shRNA (h) Lentiviral Particles - sc-77781-V from Santa Cruz Biotechnology
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Exosome component 4 RNAi - H00054512-R01 from Novus Biologicals
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MISSION® esiRNA - EHU008211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8049 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8049 from Sigma-Aldrich
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EXOSC4 siRNA (Human) - CRJ0106 from Cohesion Biosciences
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EXOSC4 - MBS8202072 from MyBioSource
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EXOSC4 CRISPR/Cas9 KO Plasmid (h2) - sc-405751-KO-2 from Santa Cruz Biotechnology
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EXOSC4 HDR Plasmid (h2) - sc-405751-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human EXOSC4 (NM_019037.2) - SHH288117 from Creative biogene
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shRNA set against Human EXOSC4(NM_019037.2) - SHH042113 from Creative biogene
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Human EXOSC4 siRNA - orb270607 from Biorbyt
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EXOSC4 shRNA Plasmid (Human) - CHJ0106 from Cohesion Biosciences
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EXOSC4 miRNA 3'UTR clone - MiUTR1H-03347 from Creative biogene
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