EXOSC4

Gene Symbol	EXOSC4
Entrez Gene	54512
Alt Symbol	RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
Species	Human
Gene Type	protein-coding
Description	exosome component 4
Other Description	exosome complex component RRP41|exosome complex exonuclease RRP41|exosome component Rrp41|ribosomal RNA-processing protein 41
Swissprots	Q9NPD3
Accessions	EAW82166 Q9NPD3 AF281133 AAF82134 AK000598 BAA91279 BC002777 AAH02777 BM839994 JF432617 ADZ15834 XM_011517133 XP_011515435 XM_011517134 XP_011515436 NM_019037 NP_061910
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC4 full length protein - ab162764 from Abcam Category Protein Source Wheat germ Species Human

Human EXOSC4 full length protein - ab176048 from Abcam Category Protein Source E. coli Species Human

Human EXOSC4 protein fragment - ab162765 from Abcam Category Protein Source Wheat germ Species Human

EXOSC4 / RRP41 Antibody Blocking Peptide - LS-E4869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Exosome component 4 Partial Recombinant Protein - H00054512-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Exosome component 4 Recombinant Protein - H00054512-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Exosome component 4 Protein - NBP2-23032 from Novus Biologicals Category Protein Prices $369.00 Sizes 100 µg Species Human

EXOSC4-Antibody-Center-Blocking-Peptide - BP17249c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC4 Blocking Peptide - 33R-8366 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC4 protein (His tag) - 80R-3548 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

EXOSC4 (1-245, His-tag) - AR51236PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

EXOSC4 (1-245, His-tag) - AR51236PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

EXOSC4 - H00054512-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EXOSC4 - H00054512-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EXOSC4 - H00054512-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC4 - H00054512-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EXOSC4, 1-245aa, Human, His tag, E.coli - 01-P2415 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

EXOSC4 fusion protein - Ag7595 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

EXOSC4 fusion protein - Ag7866 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human EXOSC4, GST-tagged - EXOSC4-12597H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human exosome component 4, His-tagged - EXOSC4-332H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component RRP41(EXOSC4) - CSB-YP889069HU CSB-EP889069HU CSB-BP889069HU CSB-MP889069HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC4, 1-245aa, Human, His tag, E.coli (Denatured) - ATGP2415 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Human EXOSC4 protein - orb259888 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Species Human

Exosome component 4 Recombinant Protein Antigen - NBP1-82170PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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