| Gene Symbol |
CST1
|
| Entrez Gene |
1469
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cystatin SN
|
| Other Description |
cystain-SA-I|cystatin 1|cystatin SA-I|cystatin-1|cystatin-SN|cysteine proteinase inhibitor, type 2 family|salivary cystatin-SA-1
|
| Swissprots |
P01037 Q9UCQ6 Q96LE6
|
| Accessions |
AAA36115 EAX10134 P01037 BC021225 AAH21225 J03870 AAA60299 NM_001898 NP_001889
|
| Function |
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:20189825}.
|
| Tissue Specificity |
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}.
|
| Top Pathways |
Salivary secretion
|
![Western Blot: Cystatin SN Overexpression Lysate (Adult Normal) [NBP2-10786] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cystatin SN.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10421_Cystatin%2520SN%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10786-img0001.jpg)