Gene Symbol | CST1 |
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Entrez Gene | 1469 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cystatin SN |
Other Description | cystain-SA-I|cystatin 1|cystatin SA-I|cystatin-1|cystatin-SN|cysteine proteinase inhibitor, type 2 family|salivary cystatin-SA-1 |
Swissprots | P01037 Q9UCQ6 Q96LE6 |
Accessions | AAA36115 EAX10134 P01037 BC021225 AAH21225 J03870 AAA60299 NM_001898 NP_001889 |
Function | Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. |
Subcellular Location | Secreted {ECO:0000269|PubMed:20189825}. |
Tissue Specificity | Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}. |
Top Pathways | Salivary secretion |
cystatin SN CRISPR/Cas9 KO Plasmid (h) - sc-405440 from Santa Cruz Biotechnology
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cystatin SN HDR Plasmid (h) - sc-405440-HDR from Santa Cruz Biotechnology
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cystatin SN Double Nickase Plasmid (h) - sc-405440-NIC from Santa Cruz Biotechnology
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cystatin SN Double Nickase Plasmid (h2) - sc-405440-NIC-2 from Santa Cruz Biotechnology
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cystatin SN CRISPR Activation Plasmid (h) - sc-405440-ACT from Santa Cruz Biotechnology
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cystatin SN CRISPR Activation Plasmid (h2) - sc-405440-ACT-2 from Santa Cruz Biotechnology
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cystatin SN Lentiviral Activation Particles (h) - sc-405440-LAC from Santa Cruz Biotechnology
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cystatin SN Lentiviral Activation Particles (h2) - sc-405440-LAC-2 from Santa Cruz Biotechnology
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cystatin S/SA/SN siRNA (h) - sc-44521 from Santa Cruz Biotechnology
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cystatin S/SA/SN shRNA Plasmid (h) - sc-44521-SH from Santa Cruz Biotechnology
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cystatin S/SA/SN shRNA (h) Lentiviral Particles - sc-44521-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU111511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6669 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6669 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01675 from Sigma-Aldrich
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CST1 siRNA (Human) - CRH1037 from Cohesion Biosciences
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CST1 - MBS8221543 from MyBioSource
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shRNA set against Human CST1 (NM_001898.2) - SHH270693 from Creative biogene
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Human CST1 siRNA - orb261539 from Biorbyt
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CST1 shRNA Plasmid (Human) - CHH1037 from Cohesion Biosciences
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CST1 miRNA 3'UTR clone - MiUTR1H-02489 from Creative biogene
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