| Gene Symbol |
SIGLEC5
|
| Entrez Gene |
8778
|
| Alt Symbol |
CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sialic acid binding Ig-like lectin 5
|
| Other Description |
CD33 antigen-like 2|OB-binding protein 2|obesity-binding protein 2|sialic acid-binding Ig-like lectin 5|sialic acid-binding immunoglobulin-like lectin 5
|
| Swissprots |
O15389
|
| Accessions |
AAF87846 AAK77223 EAW72033 O15389 AF170484 AAD50978 AK225753 BC029896 AAH29896 BX106622 DC324223 DQ892433 ABM83359 H71235 U71383 AAB70703 XM_011527438 XP_011525740 NM_003830 NP_003821
|
| Function |
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
|