| Gene Symbol |
PARG
|
| Entrez Gene |
8505
|
| Alt Symbol |
PARG99
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly (ADP-ribose) glycohydrolase
|
| Other Description |
mitochondrial poly(ADP-ribose) glycohydrolase|poly(ADP-ribose) glycohydrolase|poly(ADP-ribose) glycohydrolase 60 kDa isoform
|
| Swissprots |
Q86W56 Q7Z742 I6RUV3 B2RC24 B4DIU5 Q6E4P6 Q9Y4W7 A5YBK3 B4DYR4 Q6E4P7
|
| Accessions |
AAP83316 EAW93079 Q86W56 AF005043 AAB61614 AF085828 AK293735 BAH11584 AK295244 BAG58236 AK295786 BAG58607 AK301845 BAG63288 AK302560 BAG63826 AK307788 AY258587 AAP83314 AY575848 AAT66421 AY575849 AAT66422 BC012005 BC050560 AAH50560 BC052966 AAH52966 BU689347 DC408224 DQ867088 ABH85399 EF382674 ABR10027 JQ890226 AFM56043 XM_011540305 XP_011538607 XM_011540306 XP_011538608 XM_011540307 XP_011538609 XM_011540308 XP_011538610 XM_011540309 XP_011538611 XR_945850 NM_001303486 NP_001290415 NM_001303487 NP_001290416 NM_001303489 NP_001290418 NM_003631 NP_003622 NR_130168 NR_130169
|
| Function |
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. {ECO:0000269|PubMed:23102699}.
|
| Subcellular Location |
Isoform 5: Mitochondrion matrix.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:14527731}.
|