PARG

Gene Symbol PARG
Entrez Gene 8505
Alt Symbol PARG99
Species Human
Gene Type protein-coding
Description poly (ADP-ribose) glycohydrolase
Other Description mitochondrial poly(ADP-ribose) glycohydrolase|poly(ADP-ribose) glycohydrolase|poly(ADP-ribose) glycohydrolase 60 kDa isoform
Swissprots Q86W56 Q7Z742 I6RUV3 B2RC24 B4DIU5 Q6E4P6 Q9Y4W7 A5YBK3 B4DYR4 Q6E4P7
Accessions AAP83316 EAW93079 Q86W56 AF005043 AAB61614 AF085828 AK293735 BAH11584 AK295244 BAG58236 AK295786 BAG58607 AK301845 BAG63288 AK302560 BAG63826 AK307788 AY258587 AAP83314 AY575848 AAT66421 AY575849 AAT66422 BC012005 BC050560 AAH50560 BC052966 AAH52966 BU689347 DC408224 DQ867088 ABH85399 EF382674 ABR10027 JQ890226 AFM56043 XM_011540305 XP_011538607 XM_011540306 XP_011538608 XM_011540307 XP_011538609 XM_011540308 XP_011538610 XM_011540309 XP_011538611 XR_945850 NM_001303486 NP_001290415 NM_001303487 NP_001290416 NM_001303489 NP_001290418 NM_003631 NP_003622 NR_130168 NR_130169
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. {ECO:0000269|PubMed:23102699}.
Subcellular Location Isoform 5: Mitochondrion matrix.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:14527731}.

PARG CRISPR/Cas9 KO Plasmid (h) - sc-404382 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG HDR Plasmid (h) - sc-404382-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG Double Nickase Plasmid (h) - sc-404382-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG Double Nickase Plasmid (h2) - sc-404382-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG CRISPR Activation Plasmid (h) - sc-404382-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG CRISPR Activation Plasmid (h2) - sc-404382-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG Lentiviral Activation Particles (h) - sc-404382-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG Lentiviral Activation Particles (h2) - sc-404382-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARG siRNA (h) - sc-106355 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARG shRNA Plasmid (h) - sc-106355-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARG shRNA (h) Lentiviral Particles - sc-106355-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU229521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU118161 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16337 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16337 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07883 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07883

PARG siRNA (Human) - CRH5579 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PARG(NM_003631.2) - SHR087969 from Creative biogene

Category siRNA
Species Reactivities Human

PARG shRNA Plasmid (Human) - CHH5579 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PARG miRNA 3'UTR clone - MiUTR1H-07515 from Creative biogene

Species Reactivities Human
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