PARG

Gene Symbol PARG
Entrez Gene 8505
Alt Symbol PARG99
Species Human
Gene Type protein-coding
Description poly (ADP-ribose) glycohydrolase
Other Description mitochondrial poly(ADP-ribose) glycohydrolase|poly(ADP-ribose) glycohydrolase|poly(ADP-ribose) glycohydrolase 60 kDa isoform
Swissprots Q86W56 Q7Z742 I6RUV3 B2RC24 B4DIU5 Q6E4P6 Q9Y4W7 A5YBK3 B4DYR4 Q6E4P7
Accessions AAP83316 EAW93079 Q86W56 AF005043 AAB61614 AF085828 AK293735 BAH11584 AK295244 BAG58236 AK295786 BAG58607 AK301845 BAG63288 AK302560 BAG63826 AK307788 AY258587 AAP83314 AY575848 AAT66421 AY575849 AAT66422 BC012005 BC050560 AAH50560 BC052966 AAH52966 BU689347 DC408224 DQ867088 ABH85399 EF382674 ABR10027 JQ890226 AFM56043 XM_011540305 XP_011538607 XM_011540306 XP_011538608 XM_011540307 XP_011538609 XM_011540308 XP_011538610 XM_011540309 XP_011538611 XR_945850 NM_001303486 NP_001290415 NM_001303487 NP_001290416 NM_001303489 NP_001290418 NM_003631 NP_003622 NR_130168 NR_130169
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. {ECO:0000269|PubMed:23102699}.
Subcellular Location Isoform 5: Mitochondrion matrix.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:14527731}.

PARG (H-1) - sc-398563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PARG (H-1): sc-398563. Western blot analysis of PARG expression in SK-MEL-28 (A), T98G (B), NCI-H292 (C) and Jurkat (D) whole cell lysates.

PARG (H-300) - sc-366102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PARG (M-13) - sc-21480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARG (M-13): sc-21480. Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing cytoplasmic staining of squamous epithelial cells.

PARG (R-16) - sc-21481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARG (R-16): sc-21481. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic and nuclear staining of respiratory epithelial cells.

PARG (T-17) - sc-21478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARG (T-17): sc-21478. Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing cytoplasmic and nuclear staining of squamous epithelial cells.

Anti-PARG antibody - ab16060 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 5 : Anti-PARG antibody (ab16060)Lanes 6 - 10 : Anti-PARG antibody (ab16060) at 0.1 µgLane 1 : Hela nuclear Lane 2 : Hela WC Lane 3 : A431Lane 4 : Mouse Brain Lane 5 : Mouse Liver Lane 6 : Hela nuclear with Human PARG peptide (ab16386) at 1 µg/mlLane 7 : Hela WC with Human PARG peptide (ab16386) at 1 µg/mlLane 8 : A431 with Human PARG peptide (ab16386) at 1 µg/mlLane 9 : Mouse Brain with Human PARG peptide (ab16386) at 1 µg/mlLane 10 : Mouse Liver with Human PARG peptide (ab16386) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryAlexa Fluor Goat polyclonal to Rabbit IgG (700) (1/10,000)

Anti-PARG antibody - ab130696 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PARG antibody (ab130696) at 1/100 dilution + NCI-H292 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-PARG Antibody (aa821-849, AP) - LS-C265555 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa821-849, APC) - LS-C265556 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa821-849, Biotin) - LS-C265557 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa821-849, FITC) - LS-C265558 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa821-849, Azide-free, HRP) - LS-C265559 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa821-849, PE) - LS-C265560 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa820-849) - LS-C323784 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARG Antibody (aa770-819) - LS-C146321 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PARG antibody LS-C146321 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-PARG Antibody (aa821-849) - LS-C163367 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PARG Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The PARG antibody detected the PARG protein (arrow).

Anti-PARG Antibody (aa390-421) - LS-C100859 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Parg antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

PARG Antibody - H00008505-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: PARG Antibody [H00008505-B01P] - Analysis of PARG expression in Hela S3 NE.

PARG Antibody - NBP1-89450 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PARG Antibody [NBP1-89450] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.

Anti-PARG (C-term) antibody produced in rabbit - SAB1300403 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PARG (C-term) Antibody: <B>Cat. No. SAB1300403</B>: PARG in human breast carcinoma tissue with Anti-PARG (C-term) Antibody at 40 μg/mL.

Anti-PARG (N-term) antibody produced in rabbit - SAB1300845 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PARG (N-term) Antibody: <B>Cat. No. SAB1300845</B>: PARG in human breast carcinoma tissue with Anti-PARG (N-term) Antibody at 40 μg/mL.

Anti-PARG antibody produced in rabbit - HPA021819 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PARG: <B>Cat. No. HPA021819</B>: Immunohistochemical staining of human oral mucosa shows strong cytoplasmic positivity in squamous epithelial cells.

Anti-PARG antibody produced in mouse - SAB1400313 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-PARG, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400313</B>: Antibody concentration: 1.0 μg/mL using HeLa cells.

PARG antibody - C-terminal region (ARP63555_P050) - ARP63555_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PARG-Antibody-C-term - AP16714b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PARG Antibody (C-term) (Cat. #AP16714b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PARG antibody detected the PARG protein (arrow).
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