GADD45GIP1

Gene Symbol GADD45GIP1
Entrez Gene 90480
Alt Symbol CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1
Species Human
Gene Type protein-coding
Description growth arrest and DNA-damage-inducible, gamma interacting protein 1
Other Description 39S ribosomal protein L59, mitochondrial|CKII beta binding protein 2|CKII beta-associating protein|CR6 interacting factor 1|growth arrest and DNA damage-inducible proteins-interacting protein 1|growth arrest- and DNA damage-inducible GADD45G-interacting protein|p53-responsive gene 6 protein|papillomavirus L2 interacting nuclear protein 1
Swissprots Q9BSM6 Q8TAE8 Q8TE51 Q8IVM3 Q969P9
Accessions EAW84335 Q8TAE8 AF412816 AAL55291 AF475095 AAM10639 AF479749 AAL85877 AI309741 AJ295986 CAC82499 AJ429498 CAD22344 BC004944 AAH04944 BC013027 AAH13027 BC013039 AAH13039 BC069200 AAH69200 BI459923 HQ447517 ADQ32003 NM_052850 NP_443082
Function Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Subcellular Location Mitochondrion. Nucleus. Note=Using N- terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269|PubMed:12482659, ECO:0000269|PubMed:22453275}.
Tissue Specificity Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. {ECO:0000269|PubMed:12716909}.

CRIF1 (H-9) - sc-374122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CRIF1 (H-9): sc-374122. Western blot analysis of CRIF1 expression in F9 whole cell lysate.

CRIF1 (G-13) - sc-103445 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CRIF1 (M-222) - sc-134882 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CRIF1 (M-222): sc-134882. Western blot analysis of CRIF1 expression in mouse heart tissue extract (A) and F9 whole cell lysate (B).

CRIF1 (A-12) - sc-103443 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GADD45GIP1 antibody - ab88769 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-GADD45GIP1 antibody (ab88769) at 1 µg + A431 cell lysate at 50 µg

Anti-GADD45GIP1 antibody - ab111254 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded Human brain tissue, using 1/50 ab111254. The picture on the right is treated with the synthesized peptide

Anti-GADD45GIP1 antibody - ab118685 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GADD45GIP1 antibody (ab118685) at 1 µg/ml + HeLa cell lysate at 10 µg

Anti-GADD45GIP1 antibody - C-terminal - ab135112 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-GADD45GIP1 antibody - C-terminal (ab135112) at 1/1000 dilution + A431 total cell extract

Anti-GADD45GIP1 antibody - N-terminal - ab191304 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GADD45GIP1 antibody - N-terminal (ab191304) at 1/1000 dilution + 293 cell line lysate at 35 µgSecondaryGoat anti-rabbit IgG H&L (HRP) at 1/5000 dilution

Anti-GADD45GIP1 / CRIF1 Antibody (aa13-45) - LS-C344225 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from 293 cell line with GADD45GIP1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

Anti-GADD45GIP1 / CRIF1 Antibody - LS-C307632 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GADD45GIP1 / CRIF1 Antibody (aa91-140) - LS-C120010 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using GADD45GIP1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-GADD45GIP1 / CRIF1 Antibody (aa102-151) - LS-C145786 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GADD45GIP1 antibody LS-C145786 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

CRIF1 Antibody - NBP2-39045 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CRIF1 Antibody [NBP2-39045] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG

CRIF1 Antibody - H00090480-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CRIF1 Antibody [H00090480-B01P] - Analysis of GADD45GIP1 expression in A-431.

CRIF1 Antibody - NBP1-56039 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CRIF1 Antibody [NBP1-56039] - Analysis of paraffin-embedded human brain, using CRIF1 Antibody. The picture on the right is treated with the synthesized peptide.

GADD45GIP1 Polyclonal Antibody - bs-6008R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GADD45GIP1 antibody produced in mouse - SAB1408172 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-GADD45GIP1: <B>Cat. No. SAB1408172</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~25.4 kDa using A~431 lysate.

Anti-GADD45GIP1 (46-60) antibody produced in rabbit - SAB1102690 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human GADD45GIP1 was separated on SDS-PAGE, blotted with Anti-GADD45GIP1 (46-60) (<B>Cat. No. SAB1102690</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + GADD45GIP1 immunizing peptide (human, 46-60)

GADD45GIP1 antibody - middle region (ARP62333_P050) - ARP62333_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GADD45GIP1-Antibody-N-term - AP20586a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of MCF-7 cells using GADD45GIP1 Antibody (N-term)(green, Cat#AP20586a) compared to an isotype control of rabbit IgG(blue). AP20586a was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.

GADD45GIP1-Antibody-N-term - AW5286 from Abgent, a WuXi AppTec company

Prices $110.00, $325.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from K562,HT-29 cell line (from left to right), using GADD45GIP1 Antibody (N-term)(Cat. #AW5286). AW5286 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.

GADD45GIP1 antibody - GTX87447 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-GADD45GIP1 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX87447

GADD45GIP1 Antibody - N-terminal region (OAAB18108) - OAAB18108 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

GADD45GIP1 Antibody (OAAF03716) - OAAF03716 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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