| Gene Symbol | GADD45GIP1 |
|---|---|
| Entrez Gene | 90480 |
| Alt Symbol | CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | growth arrest and DNA-damage-inducible, gamma interacting protein 1 |
| Other Description | 39S ribosomal protein L59, mitochondrial|CKII beta binding protein 2|CKII beta-associating protein|CR6 interacting factor 1|growth arrest and DNA damage-inducible proteins-interacting protein 1|growth arrest- and DNA damage-inducible GADD45G-interacting protein|p53-responsive gene 6 protein|papillomavirus L2 interacting nuclear protein 1 |
| Swissprots | Q9BSM6 Q8TAE8 Q8TE51 Q8IVM3 Q969P9 |
| Accessions | EAW84335 Q8TAE8 AF412816 AAL55291 AF475095 AAM10639 AF479749 AAL85877 AI309741 AJ295986 CAC82499 AJ429498 CAD22344 BC004944 AAH04944 BC013027 AAH13027 BC013039 AAH13039 BC069200 AAH69200 BI459923 HQ447517 ADQ32003 NM_052850 NP_443082 |
| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Subcellular Location | Mitochondrion. Nucleus. Note=Using N- terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269|PubMed:12482659, ECO:0000269|PubMed:22453275}. |
| Tissue Specificity | Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. {ECO:0000269|PubMed:12716909}. |