| Gene Symbol |
NPR1
|
| Entrez Gene |
4881
|
| Alt Symbol |
ANPRA, ANPa, GUC2A, GUCY2A, NPRA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
natriuretic peptide receptor 1
|
| Other Description |
ANP-A|ANPR-A|GC-A|NPR-A|atrial natriuretic peptide receptor 1|atrial natriuretic peptide receptor type A|atrionatriuretic peptide receptor A|guanylate cyclase A|natriuretic peptide A type receptor|natriuretic peptide receptor A|natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
|
| Swissprots |
Q5SR08 Q6P4Q3 P16066 B0ZBF0
|
| Accessions |
AAF01340 ACA05918 ACA05919 BAA31199 BAA77020 BAB03344 BAC53955 EAW53284 P16066 AK025024 AK298090 BAH12723 AK300446 BAG62168 BC063304 AAH63304 S72628 AAD14112 X15357 CAA33417 XM_005245218 XP_005245275 XM_006711342 XP_006711405 XM_006711343 XP_006711406 XM_011509585 XP_011507887 NM_000906 NP_000897
|
| Function |
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. {ECO:0000269|PubMed:1672777}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Purine metabolism
|
![Western Blot: Natriuretic Peptide Receptor A Overexpression Lysate (Adult Normal) [NBL1-13754] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Natriuretic Peptide Receptor A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11333_Natriuretic%2520Peptide%2520Receptor%2520A%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13754-img0002.jpg)