Gene Symbol | CDC23 |
---|---|
Entrez Gene | 8697 |
Alt Symbol | ANAPC8, APC8, CUT23 |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle 23 |
Other Description | anaphase promoting complex subunit 8|anaphase-promoting complex subunit 8|cell division cycle 23 homolog|cell division cycle protein 23 homolog|cyclosome subunit 8 |
Swissprots | B7WP05 Q9UJX2 Q53FN2 B4E3A2 Q9BS73 O75433 D3DQB7 A8K6E5 |
Accessions | AAS99353 EAW62154 EAW62155 EAW62156 Q9UJX2 AB011472 BAA75628 AF053977 AAC70920 AF191341 AAF05755 AK223250 BAD96970 AK291610 BAF84299 AK304635 BAG65414 BC005258 AAH05258 BC010944 AAH10944 BC017713 AAH17713 BT009810 AAP88812 DQ891686 ABM82612 DQ894870 ABM85796 NM_004661 NP_004652 |
Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}. |
Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection |