| Gene Symbol |
SYNE4
|
| Entrez Gene |
163183
|
| Alt Symbol |
C19orf46, DFNB76, Nesp4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spectrin repeat containing, nuclear envelope family member 4
|
| Other Description |
deafness, autosomal recessive 76|nesprin-4|nuclear envelope spectrin repeat protein 4
|
| Swissprots |
A8MRS0 Q8N205 A8MYE3 Q7Z7L3
|
| Accessions |
Q8N205 AK093764 BAC04222 BC038360 BC052573 AAH52573 CB241656 XM_005258598 XP_005258655 XM_005258601 XP_005258658 XM_005258604 XP_005258661 NM_153233 NM_001039876 NP_001034965 NM_001297735 NP_001284664
|
| Function |
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}.
|