SYNE4

Gene Symbol SYNE4
Entrez Gene 163183
Alt Symbol C19orf46, DFNB76, Nesp4
Species Human
Gene Type protein-coding
Description spectrin repeat containing, nuclear envelope family member 4
Other Description deafness, autosomal recessive 76|nesprin-4|nuclear envelope spectrin repeat protein 4
Swissprots A8MRS0 Q8N205 A8MYE3 Q7Z7L3
Accessions Q8N205 AK093764 BAC04222 BC038360 BC052573 AAH52573 CB241656 XM_005258598 XP_005258655 XM_005258601 XP_005258658 XM_005258604 XP_005258661 NM_153233 NM_001039876 NP_001034965 NM_001297735 NP_001284664
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}.
Subcellular Location Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}.

C19orf46 CRISPR/Cas9 KO Plasmid (h) - sc-407273 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 HDR Plasmid (h) - sc-407273-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 Double Nickase Plasmid (h) - sc-407273-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 Double Nickase Plasmid (h2) - sc-407273-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 CRISPR Activation Plasmid (h) - sc-407273-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 CRISPR Activation Plasmid (h2) - sc-407273-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 Lentiviral Activation Particles (h) - sc-407273-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C19orf46 Lentiviral Activation Particles (h2) - sc-407273-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Syne-4 siRNA (h) - sc-97818 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Syne-4 shRNA Plasmid (h) - sc-97818-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Syne-4 shRNA (h) Lentiviral Particles - sc-97818-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU062991 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4541 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4541 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SYNE4 siRNA (Human) - CRJ5983 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SYNE4 - MBS8232777 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C19orf46 (NM_001039876.1) - SHH250166 from Creative biogene

Category siRNA
Species Reactivities Human

SYNE4 shRNA Plasmid (Human) - CHJ5983 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SYNE4 miRNA 3'UTR clone - MiUTR1H-01207 from Creative biogene

Species Reactivities Human
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