SYNE4

Gene Symbol SYNE4
Entrez Gene 163183
Alt Symbol C19orf46, DFNB76, Nesp4
Species Human
Gene Type protein-coding
Description spectrin repeat containing, nuclear envelope family member 4
Other Description deafness, autosomal recessive 76|nesprin-4|nuclear envelope spectrin repeat protein 4
Swissprots A8MRS0 Q8N205 A8MYE3 Q7Z7L3
Accessions Q8N205 AK093764 BAC04222 BC038360 BC052573 AAH52573 CB241656 XM_005258598 XP_005258655 XM_005258601 XP_005258658 XM_005258604 XP_005258661 NM_153233 NM_001039876 NP_001034965 NM_001297735 NP_001284664
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}.
Subcellular Location Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}.

Syne-4 (K-17) - sc-241271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-C19orf46 antibody - ab73050 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-C19orf46 antibody (ab73050) at 1/500 dilutionLane 1 : C19orf46 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilutionObserved band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-SYNE4 / C19orf46 Antibody (N-Terminus) - LS-C201481 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human ACHN. SYNE4 antibody dilution 1.0 ug/ml.

Anti-SYNE4 / C19orf46 Antibody (aa38-87) - LS-C82487 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Nesprin-4 Antibody - NBP2-31811 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Nesprin-4 Antibody [NBP2-31811] - Staining of human cerebellum shows strong nuclear positivity in Purkinje cells.

Nesprin-4 Antibody - NBP1-59767 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Nesprin-4 Antibody [NBP1-59767] - 293T cells lysate, concentration 0.2-1 ug/ml.

Nesprin-4 Antibody - H00163183-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of FLJ36445 expression in transfected 293T cell line by FLJ36445 MaxPab polyclonal antibody (B01). Lane 1: FLJ36445 transfected lysate (31.00 KDa). Lane 2: Non-transfected lysate.

C19orf46 Polyclonal Antibody - bs-9682R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
A549 (hu) lysates probed with C19orf46 Polyclonal Antibody, unconjugated (bs-9682R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 60 minutes at 37°C.

Anti-C19ORF46 antibody produced in rabbit - SAB2100265 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-C19ORF46: <B>Cat. No.SAB2100265</B>: C19orf46 in 293T cell lysate with C19orf46 antibody at 1.0 μg/mL.

SYNE4 Antibody - N-terminal region (ARP44894_P050) - ARP44894_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 antibody - N-terminal region (ARP44895_P050) - ARP44895_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nesprin 4 antibody, N-term - GTX46600 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

C19ORF46 antibody - 70R-6674 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

C19orf46 antibody - H00163183-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

C19orf46 Antibody - GWB-MP978F from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-C19ORF46 (aa 38-87) polyclonal antibody - DPABH-11570 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-C19ORF46 (aa 6-55) polyclonal antibody - DPABH-13126 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-C19ORF46 monoclonal antibody - DCABH-14774 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

C19orf46 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-9682R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-9682R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-9682R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-9682R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 Polyclonal Antibody, Cy3 Conjugated - bs-9682R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 Polyclonal Antibody, Cy5 Conjugated - bs-9682R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf46 Polyclonal Antibody, Cy5.5 Conjugated - bs-9682R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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