SYNE4

Gene Symbol	SYNE4
Entrez Gene	163183
Alt Symbol	C19orf46, DFNB76, Nesp4
Species	Human
Gene Type	protein-coding
Description	spectrin repeat containing, nuclear envelope family member 4
Other Description	deafness, autosomal recessive 76|nesprin-4|nuclear envelope spectrin repeat protein 4
Swissprots	A8MRS0 Q8N205 A8MYE3 Q7Z7L3
Accessions	Q8N205 AK093764 BAC04222 BC038360 BC052573 AAH52573 CB241656 XM_005258598 XP_005258655 XM_005258601 XP_005258658 XM_005258604 XP_005258661 NM_153233 NM_001039876 NP_001034965 NM_001297735 NP_001284664
Function	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C19orf46 full length protein - ab165757 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

SYNE4 / C19orf46 Antibody Blocking Peptide - LS-E16486 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Nesprin-4 Protein - H00163183-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

C19orf46-Antibody-Center-Blocking-Peptide - BP9391c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

C19ORF46 Blocking Peptide - 33R-3224 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

C19orf46 - H00163183-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

C19orf46 - H00163183-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human Nesprin-4(C19orf46) - CSB-YP847615HU CSB-EP847615HU CSB-BP847615HU CSB-MP847615HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Nesprin-4 Recombinant Protein Antigen - NBP2-31811PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SYNE4 Peptide, Human - M34GP15471H from Creative Peptides Category Peptide Source Synthetic. Species Human

C19orf46 fusion protein - Ag24107 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Nesprin-4 (C19orf46), Recombinant Protein - MBS1457317 from MyBioSource Category Protein Prices $1,120.00, $1,120.00, $1,350.00, $1,350.00, $1,775.00, $1,775.00, $2,240.00, $2,240.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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