LCLAT1

Gene Symbol LCLAT1
Entrez Gene 253558
Alt Symbol 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
Species Human
Gene Type protein-coding
Description lysocardiolipin acyltransferase 1
Other Description 1-AGP acyltransferase 8|1-AGPAT 8|1-acylglycerol-3-phosphate O-acyltransferase 8|acyl-CoA:lysocardiolipin acyltransferase 1
Swissprots Q6UWP7 Q8N1Q7 A6H8Z7
Accessions EAX00495 Q6UWP7 AA455668 AK023269 AK095284 BAC04522 AK296965 BAG59509 AK297262 BAG59738 AK302562 BAG63827 AK311294 AY358702 AAQ89065 BC146817 AAI46818 BF439401 BF513499 BP872689 BU674604 BX537607 BX647953 CF264801 XM_005264244 XP_005264301 XM_005264245 XP_005264302 XM_011532741 XP_011531043 XM_011532742 XP_011531044 XM_011532743 XP_011531045 XM_011532744 XP_011531046 XM_011532745 XP_011531047 NM_001002257 NP_001002257 NM_001304445 NP_001291374 NM_001304446 NP_001291375 NM_182551 NP_872357
Function Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000269|PubMed:19075029}.
Tissue Specificity Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Top Pathways Glycerolipid metabolism, Glycerophospholipid metabolism

LYCAT (E-14) - sc-168512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-LCLAT1 antibody - ab153987 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LCLAT1 antibody (ab153987) at 1/500 dilutionLane 1 : HeLa whole cell lysateLane 2 : HeLa membrane lysateLysates/proteins at 20 µg per lane.

Anti-LCLAT1 antibody - ab122197 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122197 at 1/450 dilution staining LCLAT1 in Paraffin-embedded Human Heart muscle tissue by Immunohistochemistry.

Anti-LCLAT1 antibody - C-terminal - ab175516 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human lung carcinoma tissue labeling LCLAT1 with ab175516 at 1/50 followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-LCLAT1 Antibody (C-Terminus, AP) - LS-C237048 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus, Biotin) - LS-C237049 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus, APC) - LS-C237051 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus, FITC) - LS-C237050 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus, PE) - LS-C237054 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus, Azide-free, HRP) - LS-C248693 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus) - LS-C322611 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LCLAT1 Antibody (C-Terminus) - LS-C110943 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LCLAT1 antibody LS-C110943 Western blot of 721_B cell lysate.

Anti-LCLAT1 Antibody (aa296-324) - LS-C165718 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LCLT1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

LCLAT1 Antibody - NBP1-59347 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

LCLAT1 Antibody - 44890002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: LCLAT1 Antibody [44890002]

LCLAT1 Antibody - NBP2-14187 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: LCLAT1 Antibody [NBP2-14187] - Staining of human heart muscle shows cytoplasmic positivity in myocytes.

LCLAT1 Antibody - NBP1-89204 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: LCLAT1 Antibody [NBP1-89204] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes.

LCLAT1 Antibody - NBP2-19339 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LCLAT1 Antibody [NBP2-19339] - Sample (20 ug of whole cell lysate) A: HeLa B: HeLa membrane, 10% SDS PAGE gel, diluted at 1:500.

Anti-LCLAT1 antibody produced in rabbit - HPA049217 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LCLAT1:<B>Cat. No. HPA049217</B>: Immunohistochemical staining of human pancreas shows strong membranous positivity in exocrine glandular cells.

Anti-LCLAT1 antibody produced in rabbit - SAB2700933 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LCLAT1: <B>Cat. No. SAB2700933</B>: Western Blot analysis of LCLAT1 in extracts from <B>Lanes</B><BR/>A. HeLa <BR/>B. HeLa membrane fraction using <B>Cat. No. SAB2700933</B> at a 1:500 dilution.

Anti-LCLAT1 antibody produced in rabbit - HPA031880 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LCLAT1: <B>Cat. No. HPA031880</B>: Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes.

Anti-LYCAT antibody produced in rabbit - SAB2101405 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LYCAT: <B>Cat. No.SAB2101405</B>: LYCAT in 721_B cell lysate with LYCAT antibody at 1.0 μg/mL.

LYCAT antibody - middle region (ARP44426_P050) - ARP44426_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

LCLAT1 Antibody - C-terminal region (OAAB03131) - OAAB03131 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

LCLT1-Antibody-C-term - AP5723b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
LCLT1 Antibody (C-term) (Cat. #AP5723b) western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the LCLT1 antibody detected LCLT1 protein (arrow).
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