LCLAT1

Gene Symbol LCLAT1
Entrez Gene 253558
Alt Symbol 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
Species Human
Gene Type protein-coding
Description lysocardiolipin acyltransferase 1
Other Description 1-AGP acyltransferase 8|1-AGPAT 8|1-acylglycerol-3-phosphate O-acyltransferase 8|acyl-CoA:lysocardiolipin acyltransferase 1
Swissprots Q6UWP7 Q8N1Q7 A6H8Z7
Accessions EAX00495 Q6UWP7 AA455668 AK023269 AK095284 BAC04522 AK296965 BAG59509 AK297262 BAG59738 AK302562 BAG63827 AK311294 AY358702 AAQ89065 BC146817 AAI46818 BF439401 BF513499 BP872689 BU674604 BX537607 BX647953 CF264801 XM_005264244 XP_005264301 XM_005264245 XP_005264302 XM_011532741 XP_011531043 XM_011532742 XP_011531044 XM_011532743 XP_011531045 XM_011532744 XP_011531046 XM_011532745 XP_011531047 NM_001002257 NP_001002257 NM_001304445 NP_001291374 NM_001304446 NP_001291375 NM_182551 NP_872357
Function Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000269|PubMed:19075029}.
Tissue Specificity Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Top Pathways Glycerolipid metabolism, Glycerophospholipid metabolism

LYCAT CRISPR/Cas9 KO Plasmid (h) - sc-415182 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT HDR Plasmid (h) - sc-415182-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT Double Nickase Plasmid (h) - sc-415182-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT Double Nickase Plasmid (h2) - sc-415182-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT CRISPR Activation Plasmid (h) - sc-415182-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT CRISPR Activation Plasmid (h2) - sc-415182-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT Lentiviral Activation Particles (h) - sc-415182-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT Lentiviral Activation Particles (h2) - sc-415182-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LYCAT siRNA (h) - sc-94958 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LYCAT shRNA Plasmid (h) - sc-94958-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LYCAT shRNA (h) Lentiviral Particles - sc-94958-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU092301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11598 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11598 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LCLAT1 siRNA (Human) - CRJ6644 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LCLAT1 (NM_182551.3) - SHH328987 from Creative biogene

Category siRNA
Species Reactivities Human

Human LCLAT1 siRNA - orb277145 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LCLAT1 shRNA Plasmid (Human) - CHJ6644 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LCLAT1 miRNA 3'UTR clone - MiUTR1H-05964 from Creative biogene

Species Reactivities Human

LCLAT1 miRNA 3'UTR clone - MiUTR1H-05965 from Creative biogene

Species Reactivities Human
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