| Gene Symbol |
LCLAT1
|
| Entrez Gene |
253558
|
| Alt Symbol |
1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysocardiolipin acyltransferase 1
|
| Other Description |
1-AGP acyltransferase 8|1-AGPAT 8|1-acylglycerol-3-phosphate O-acyltransferase 8|acyl-CoA:lysocardiolipin acyltransferase 1
|
| Swissprots |
Q6UWP7 Q8N1Q7 A6H8Z7
|
| Accessions |
EAX00495 Q6UWP7 AA455668 AK023269 AK095284 BAC04522 AK296965 BAG59509 AK297262 BAG59738 AK302562 BAG63827 AK311294 AY358702 AAQ89065 BC146817 AAI46818 BF439401 BF513499 BP872689 BU674604 BX537607 BX647953 CF264801 XM_005264244 XP_005264301 XM_005264245 XP_005264302 XM_011532741 XP_011531043 XM_011532742 XP_011531044 XM_011532743 XP_011531045 XM_011532744 XP_011531046 XM_011532745 XP_011531047 NM_001002257 NP_001002257 NM_001304445 NP_001291374 NM_001304446 NP_001291375 NM_182551 NP_872357
|
| Function |
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000269|PubMed:19075029}.
|
| Tissue Specificity |
Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|