LCLAT1

Gene Symbol LCLAT1
Entrez Gene 253558
Alt Symbol 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
Species Human
Gene Type protein-coding
Description lysocardiolipin acyltransferase 1
Other Description 1-AGP acyltransferase 8|1-AGPAT 8|1-acylglycerol-3-phosphate O-acyltransferase 8|acyl-CoA:lysocardiolipin acyltransferase 1
Swissprots Q6UWP7 Q8N1Q7 A6H8Z7
Accessions EAX00495 Q6UWP7 AA455668 AK023269 AK095284 BAC04522 AK296965 BAG59509 AK297262 BAG59738 AK302562 BAG63827 AK311294 AY358702 AAQ89065 BC146817 AAI46818 BF439401 BF513499 BP872689 BU674604 BX537607 BX647953 CF264801 XM_005264244 XP_005264301 XM_005264245 XP_005264302 XM_011532741 XP_011531043 XM_011532742 XP_011531044 XM_011532743 XP_011531045 XM_011532744 XP_011531046 XM_011532745 XP_011531047 NM_001002257 NP_001002257 NM_001304445 NP_001291374 NM_001304446 NP_001291375 NM_182551 NP_872357
Function Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000269|PubMed:19075029}.
Tissue Specificity Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Top Pathways Glycerolipid metabolism, Glycerophospholipid metabolism

LCLAT1 overexpression lysate - LY405476 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

LCLAT1 Overexpression Lysate (Native) - NBP2-04843 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: LCLAT1 Overexpression Lysate (Adult Normal) [NBP2-04843] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LCLAT1.

Panoply™ Human LCLAT1 Knockdown Stable Cell Line - CSC-DC008590 from Creative biogene

Category Cell Line
Species Human
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