ERN1

Gene Symbol ERN1
Entrez Gene 2081
Alt Symbol IRE1, IRE1P, IRE1a, hIRE1p
Species Human
Gene Type protein-coding
Description endoplasmic reticulum to nucleus signaling 1
Other Description ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1
Swissprots A8K8N8 A1L457 A8MXS7 Q59EE2 O75460
Accessions EAW94213 EAW94214 O75460 AB209869 BAD93106 AF059198 AAC25991 AI791744 AI792619 AK055561 AK124426 AK292403 BAF85092 AL698247 BC070350 BC130405 AAI30406 BC130407 AAI30408 BF817483 BF846361 DB128514 NM_001433 NP_001424 NM_152461
Function Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250|UniProtKB:Q9EQY0, ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
Tissue Specificity Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
Top Pathways Alzheimer's disease, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD)

IRE1α (14C10) Rabbit mAb - 3294 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 14C10
Western blot analysis of extracts from various cell lines, using IRE1α (14C10) Rabbit mAb.

IRE1α (B-12) - sc-390960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRE1α (B-12): sc-390960. Western blot analysis of IRE1α expression in DU 145 (A) and HeLa (B) whole cell lysates.

IRE1α (H-190) - sc-20790 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRE1α CRISPR/Cas9 KO Plasmid (h): sc-400576. Western blot analysis of human IRE1α expression in empty vector control (A) and IRE1a CRISPR/Cas9 KO Plasmid transfected (B) HEK293T whole cell lysates. Blot probed with IRE1α (H-190): sc-20790. α-actinin (H-2): sc-17829 used as specificity and loading control.

IRE1α (L-19) - sc-31199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IRE1α (L-19): sc-31199. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic and nuclear staining of exocrine glandular cells and Islets of Langerhans.

IRE1α (C-17) - sc-10510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IRE1α (C-17): sc-10510. Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymis tissue showing cytoplasmic, membrane and nuclear staining of glandular cells.

IRE1α (YB-17) - sc-100772 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IRE1α (YB-17): sc-100772. Western blot analysis of IRE1α expression in HeLa whole cell lysate.

Anti-ERN1 / IRE1 Antibody (aa200-300) IHC-plus™ - LS-B12187 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ERN1 / IRE1 Antibody (C-Terminus) IHC-plus™ - LS-B8029 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ERN1 / IRE1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8029 dilution 5 ug/ml.

Anti-ERN1 / IRE1 Antibody (clone 9F2) IHC-plus™ - LS-B4154 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 9F2
Anti-ERN1 / IRE1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4154 dilution 1:200.

Anti-ERN1 / IRE1 Antibody (Internal) - LS-C19556 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of IRE1p in Raji cell lysate with IRE1p antibody at (A) 1 and (B) 2 ug/ml.

Anti-ERN1 / IRE1 Antibody (aa700-800, Biotin) - LS-C140982 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa700-800, DY650) - LS-C140983 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa700-800, DY488) - LS-C140984 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa700-800, HRP) - LS-C140985 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa700-800, DY550) - LS-C140986 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa200-300, Biotin) - LS-C141644 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa200-300, DY650) - LS-C141645 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa200-300, DY488) - LS-C141646 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (phospho-Ser724, clone EPR5253) - LS-C138648 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5253
Western blot analysis on 293T cell lysates using anti-Phospho-IRE1 (pS724) antibody. Cells were either (A) untreated (B) treated with Calyculin A.

Anti-ERN1 / IRE1 Antibody (aa200-300, HRP) - LS-C141647 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (N-Terminus) - LS-C19555 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of IRE1p in A20 cells with IRE1p antibody at 1 ug/ml.

Anti-ERN1 / IRE1 Antibody (aa200-300, DY550) - LS-C141648 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa827-855, AP) - LS-C213963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERN1 / IRE1 Antibody (aa699-711) - LS-C87281 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.03 ug/ml) staining of Human Pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

Anti-ERN1 / IRE1 Antibody (aa827-855, APC) - LS-C213964 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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