ERN1

Gene Symbol	ERN1
Entrez Gene	2081
Alt Symbol	IRE1, IRE1P, IRE1a, hIRE1p
Species	Human
Gene Type	protein-coding
Description	endoplasmic reticulum to nucleus signaling 1
Other Description	ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1
Swissprots	A8K8N8 A1L457 A8MXS7 Q59EE2 O75460
Accessions	EAW94213 EAW94214 O75460 AB209869 BAD93106 AF059198 AAC25991 AI791744 AI792619 AK055561 AK124426 AK292403 BAF85092 AL698247 BC070350 BC130405 AAI30406 BC130407 AAI30408 BF817483 BF846361 DB128514 NM_001433 NP_001424 NM_152461
Function	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250|UniProtKB:Q9EQY0, ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
Tissue Specificity	Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
Top Pathways	Alzheimer's disease, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IRE1 (phospho S724) peptide - ab133861 from Abcam Category Peptide Species Human

Human IRE1 full length protein - ab132928 from Abcam Category Protein Source Wheat germ Species Human

Human IRE1 peptide - ab39786 from Abcam Category Peptide Species Human

Human IRE1 peptide - ab39783 from Abcam Category Peptide Species Human

Human IRE1 protein fragment - ab114174 from Abcam Category Protein Source Wheat germ Species Human

IRE1 peptide - phospho S724 - ab110445 from Abcam Category Peptide

ERN1 / IRE1 Antibody Blocking Peptide - LS-E3111 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERN1 / IRE1 Antibody Blocking Peptide - LS-E5297 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERN1 / IRE1 Antibody Blocking Peptide - LS-E30196 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERN1 / IRE1 Antibody Blocking Peptide - LS-E30195 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERN1 / IRE1 Antibody Blocking Peptide - LS-E30197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERN1 / IRE1 Antibody Blocking Peptide - LS-E26727 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRE1 alpha Peptide - NB100-2324PEP from Novus Biologicals Category Peptide Prices $99.00 Sizes 50 µg

IRE1 alpha [p Ser724] Blocking Peptide - NB100-2323PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

IRE1 alpha Blocking Peptide - NB110-59971PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human IRE1 alpha Protein - H00002081-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IRE1 alpha Protein - H00002081-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERN1-Antibody-C-term-Blocking-Peptide - BP17747b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRE1 alpha blocking peptide - GTX88550-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

IRE1 alpha blocking peptide - GTX89885-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human ERN1 protein - orb138823 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

ERN1 Immunizing peptide - orb16220 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

IRE1 Peptide - AC21-1565-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ERN1 / IRE1 - H00002081-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ERN1 / IRE1 - H00002081-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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