| Gene Symbol | ERN1 |
|---|---|
| Entrez Gene | 2081 |
| Alt Symbol | IRE1, IRE1P, IRE1a, hIRE1p |
| Species | Human |
| Gene Type | protein-coding |
| Description | endoplasmic reticulum to nucleus signaling 1 |
| Other Description | ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1 |
| Swissprots | A8K8N8 A1L457 A8MXS7 Q59EE2 O75460 |
| Accessions | EAW94213 EAW94214 O75460 AB209869 BAD93106 AF059198 AAC25991 AI791744 AI792619 AK055561 AK124426 AK292403 BAF85092 AL698247 BC070350 BC130405 AAI30406 BC130407 AAI30408 BF817483 BF846361 DB128514 NM_001433 NP_001424 NM_152461 |
| Function | Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250|UniProtKB:Q9EQY0, ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}. |
| Tissue Specificity | Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}. |
| Top Pathways | Alzheimer's disease, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD) |