ERN1

Gene Symbol	ERN1
Entrez Gene	2081
Alt Symbol	IRE1, IRE1P, IRE1a, hIRE1p
Species	Human
Gene Type	protein-coding
Description	endoplasmic reticulum to nucleus signaling 1
Other Description	ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1
Swissprots	A8K8N8 A1L457 A8MXS7 Q59EE2 O75460
Accessions	EAW94213 EAW94214 O75460 AB209869 BAD93106 AF059198 AAC25991 AI791744 AI792619 AK055561 AK124426 AK292403 BAF85092 AL698247 BC070350 BC130405 AAI30406 BC130407 AAI30408 BF817483 BF846361 DB128514 NM_001433 NP_001424 NM_152461
Function	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250|UniProtKB:Q9EQY0, ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
Tissue Specificity	Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
Top Pathways	Alzheimer's disease, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ERN1 / IRE1 ELISA Kit (Sandwich ELISA) - LS-F8896 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human ERN1 / IRE1 ELISA Kit (Sandwich ELISA) - LS-F11390 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human ERN1 ELISA Kit - abx151448 from Abbexa Category ELISA Kit Sensitivity 0.071 ng/ml Range 0.156 ng/ml - 10 ng/ml

Endoplasmic Reticulum To Nucleus Signalling 1 (ERN1), Human, ELISA Kit - SEC460Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.071ng/mL Range 0.156-10ng/mL

Endoplasmic Reticulum to Nucleus Signalling 1, ERN1, Human, ELISA Kit - E-EL-H1764 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1), Human, ELISA Kit - CSB-EL007795HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Serine/threonine-protein kinase/endoribonuclease IRE1, ERN1, Human, ELISA Kit - E7165h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.312-20 ng/mL

Endoplasmic Reticulum To Nucleus Signalling 1, ERN1, Mouse, ELISA Kit - E-EL-M0452 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 23.438 Range 39.063-2500pg/mL

Endoplasmic Reticulum To Nucleus Signalling 1, ERN1, Rat, ELISA Kit - E-EL-R0363 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Endoplasmic Reticulum to Nucleus Signalling 1, ERN1, Rabbit, ELISA Kit - E-EL-RB1972 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Endoplasmic Reticulum to Nucleus Signalling 1, ERN1, Chicken, ELISA Kit - E-EL-Ch0408 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Endoplasmic Reticulum to Nucleus Signalling 1, ERN1, Porcine, ELISA Kit - E-EL-P0681 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Endoplasmic Reticulum to Nucleus Signalling 1, ERN1, Guinea Pig, ELISA Kit - E-EL-GP0885 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Endoplasmic Reticulum to Nucleus Signalling 1, ERN1, Monkey, ELISA Kit - E-EL-MK1807 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human ERN1 ELISA Kit - HE0067 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine ERN1 ELISA Kit - AE0067 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

endoplasmic reticulum to nucleus signaling 1, ELISA Kit - MBS906095 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.86 pg/ml Range 23.5 pg/ml-1500 pg/ml

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS727301 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS731683 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS749640 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS727376 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS746851 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ERN1(Endoplasmic Reticulum to Nucleus Signalling 1) ELISA Kit - E-EL-H1764 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS750226 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Endoplasmic Reticulum To Nucleus Signalling 1, ELISA Kit - MBS729250 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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