PTPN6

Gene Symbol	PTPN6
Entrez Gene	5777
Alt Symbol	HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 6
Other Description	hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6
Swissprots	Q9UK67 P29350 G3V0F8 Q969V8 A8K306
Accessions	AAA82879 AAA82880 AAB51322 AAB51323 BAC81774 BAC81775 CBX47486 CBX47487 EAW88700 EAW88701 EAW88702 EAW88703 EAW88704 P29350 AF178946 AAD53317 AK223629 BAD97349 AK290421 BAF83110 AK298470 BAG60682 AK300167 BAG61949 AK308230 AK309037 AK313379 BAG36177 BC002523 AAH02523 BC007667 AAH07667 BG754792 BM006699 BM742181 BT007390 AAP36054 CR986427 DA431502 DA868001 DC297194 DQ891946 ABM82872 DQ895133 ABM86059 M74903 AAA35963 M77273 AAA36610 XM_006718994 XP_006719057 XM_011520988 XP_011519290 XM_011520989 XP_011519291 XR_931520 NM_002831 NP_002822 NM_080548 NP_536858 NM_080549 NP_536859
Function	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}.
Subcellular Location	Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.
Tissue Specificity	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Top Pathways	Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PTPN6-Over-expression-Lysate - LY10037a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PTPN6 Lysate(Denatured) - H00005777-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PTPN6 overexpression lysate - LY401007 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PTPN6 293 Cell Lysate - 400945 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PTPN6 293 Cell Lysate - 404868 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PTPN6 Overexpression Lysate (Denatured) - H00005777-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PTPN6 Overexpression Lysate (Native) - NBP2-05773 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PTPN6 Overexpression Lysate (Native) - NBL1-14976 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SH-PTP1 (h): 293T Lysate - sc-176633 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PTPN6 Over-expression Lysate Product - GWB-E60F80 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

PTPN6 Over-expression Lysate Product - GWB-705B43 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human PTPN6 Knockdown Stable Cell Line - CSC-DC012709 from Creative biogene Category Cell Line Species Human

PTPN6 Knockout Cell Line-HeLa - CSC-RT1953 from Creative biogene Category Cell Line Species Human

PTPN6 KO Cell Lysate-HeLa - CLKO-1702 from Creative biogene Category Cell Lysate

PTPN6 KO Cell Lysate-HeLa - CLKO-1810 from Creative biogene Category Cell Lysate

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