PTPN6

Gene Symbol	PTPN6
Entrez Gene	5777
Alt Symbol	HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 6
Other Description	hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6
Swissprots	Q9UK67 P29350 G3V0F8 Q969V8 A8K306
Accessions	AAA82879 AAA82880 AAB51322 AAB51323 BAC81774 BAC81775 CBX47486 CBX47487 EAW88700 EAW88701 EAW88702 EAW88703 EAW88704 P29350 AF178946 AAD53317 AK223629 BAD97349 AK290421 BAF83110 AK298470 BAG60682 AK300167 BAG61949 AK308230 AK309037 AK313379 BAG36177 BC002523 AAH02523 BC007667 AAH07667 BG754792 BM006699 BM742181 BT007390 AAP36054 CR986427 DA431502 DA868001 DC297194 DQ891946 ABM82872 DQ895133 ABM86059 M74903 AAA35963 M77273 AAA36610 XM_006718994 XP_006719057 XM_011520988 XP_011519290 XM_011520989 XP_011519291 XR_931520 NM_002831 NP_002822 NM_080548 NP_536858 NM_080549 NP_536859
Function	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}.
Subcellular Location	Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.
Tissue Specificity	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Top Pathways	Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SHP1 full length protein - ab61135 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source E. coli Species Human

Active human SHP1 full length protein - ab80217 from Abcam Category Protein Prices $294.00 Sizes 20 µg Source E. coli Species Human

Active human SHP1 protein fragment - ab51289 from Abcam Category Protein Prices $308.00, $939.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human SHP1 peptide - ab42772 from Abcam Category Peptide Species Human

Human SHP1 peptide - ab42773 from Abcam Category Peptide Species Human

Human SHP1 peptide - ab82208 from Abcam Category Peptide

PTPN6 / SHP1 Antibody Blocking Peptide - LS-E22448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN6 / SHP1 Antibody Blocking Peptide - LS-E26307 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN6 / SHP1 Antibody Blocking Peptide - LS-E26308 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN6 Recombinant Protein - H00005777-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PTPN6 Protein - NBC1-18382 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

PTPN6 Recombinant Protein - P3445 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Species Human

SHP1 (internal region) blocking peptide - GTX89108-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

SHP1 (internal) blocking peptide - GTX89061-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Active SHP-1 (aa 205-595), CF - 1878-SH-010 from R&D Systems Category Protein Source E. coli-derived, Ala205-Lys595, with an N-terminal Met and 6-His tag (C-terminal variants predicted)

PTPN6 Protein (OPPA01135) - OPPA01135 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Protein Tyrosine Phosphatase Non Receptor Type-6 protein - orb80868 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

PTPN6 Blocking Peptide - 33R-9938 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SHP1 protein - 30R-1028 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

SHP1 Peptide - AC21-1142-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SHP1 Peptide - AC21-1143-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PTPN6 (243-541) - SA6015 from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

PTPN6 (243-541) - SA6015X from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

PTPN6 - H00005777-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PTPN6 - H00005777-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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