PTPN6
| Gene Symbol | PTPN6 |
|---|---|
| Entrez Gene | 5777 |
| Alt Symbol | HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, non-receptor type 6 |
| Other Description | hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6 |
| Swissprots | Q9UK67 P29350 G3V0F8 Q969V8 A8K306 |
| Accessions | AAA82879 AAA82880 AAB51322 AAB51323 BAC81774 BAC81775 CBX47486 CBX47487 EAW88700 EAW88701 EAW88702 EAW88703 EAW88704 P29350 AF178946 AAD53317 AK223629 BAD97349 AK290421 BAF83110 AK298470 BAG60682 AK300167 BAG61949 AK308230 AK309037 AK313379 BAG36177 BC002523 AAH02523 BC007667 AAH07667 BG754792 BM006699 BM742181 BT007390 AAP36054 CR986427 DA431502 DA868001 DC297194 DQ891946 ABM82872 DQ895133 ABM86059 M74903 AAA35963 M77273 AAA36610 XM_006718994 XP_006719057 XM_011520988 XP_011519290 XM_011520989 XP_011519291 XR_931520 NM_002831 NP_002822 NM_080548 NP_536858 NM_080549 NP_536859 |
| Function | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. |
| Top Pathways | Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway |
SH-PTP1 CRISPR/Cas9 KO Plasmid (h) - sc-400369 from Santa Cruz Biotechnology
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SH-PTP1 HDR Plasmid (h) - sc-400369-HDR from Santa Cruz Biotechnology
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SH-PTP1 Double Nickase Plasmid (h) - sc-400369-NIC from Santa Cruz Biotechnology
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SH-PTP1 Double Nickase Plasmid (h2) - sc-400369-NIC-2 from Santa Cruz Biotechnology
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SH-PTP1 CRISPR Activation Plasmid (h) - sc-400369-ACT from Santa Cruz Biotechnology
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SH-PTP1 CRISPR Activation Plasmid (h2) - sc-400369-ACT-2 from Santa Cruz Biotechnology
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SH-PTP1 Lentiviral Activation Particles (h) - sc-400369-LAC from Santa Cruz Biotechnology
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SH-PTP1 Lentiviral Activation Particles (h2) - sc-400369-LAC-2 from Santa Cruz Biotechnology
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SH-PTP1 siRNA (h) - sc-29478 from Santa Cruz Biotechnology
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SH-PTP1 shRNA Plasmid (h) - sc-29478-SH from Santa Cruz Biotechnology
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SH-PTP1 shRNA (h) Lentiviral Particles - sc-29478-V from Santa Cruz Biotechnology
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SH-PTP1 siRNA (h2) - sc-270492 from Santa Cruz Biotechnology
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SH-PTP1 shRNA Plasmid (h2) - sc-270492-SH from Santa Cruz Biotechnology
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PTPN6 RNAi - H00005777-R03 from Novus Biologicals
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PTPN6 RNAi - H00005777-R01 from Novus Biologicals
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MISSION® esiRNA - EHU066321 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0771 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0770 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0769 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1061 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01242 from Sigma-Aldrich
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PTPN6 siRNA (Human) - CRH3901 from Cohesion Biosciences
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PTPN6 RNAi - H00005777-R02 from Novus Biologicals
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shRNA set against Human Ptpn6 (NM_002831.5) - SHH386600 from Creative biogene
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