BARD1

Gene Symbol	BARD1
Entrez Gene	580
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	BRCA1 associated RING domain 1
Other Description	BRCA1-associated RING domain gene 1|BRCA1-associated RING domain protein 1
Swissprots	F6MDH8 F6MDH7 Q99728 Q53SS5 O43574 F6MDH9
Accessions	AAB99978 AAX93130 EAW70519 Q99728 AK223409 BAD97129 AK301843 BAG63286 AK310759 AK314260 BAG36925 AX794378 CAE48237 BC126426 AAI26427 BC126428 AAI26429 BU677525 BU753556 BX098964 DB088853 JF790280 AEF57471 JF790281 AEF57472 JF790282 AEF57473 JF790283 AEF57474 JF790284 AEF57475 JF790285 AEF57476 JF790286 AEF57477 JF790287 AEF57478 U76638 AAB38316 XM_011511567 XP_011509869 XM_011511568 XP_011509870 NM_000465 NP_000456 NM_001282543 NP_001269472 NM_001282545 NP_001269474 NM_001282548 NP_001269477 NM_001282549 NP_001269478 NR_104212 NR_104215 NR_104216
Function	Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}.
Subcellular Location	Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BARD1 peptide - ab74356 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human BARD1 peptide - ab23008 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human BARD1 protein fragment - ab114640 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

BARD1 Antibody Blocking Peptide - LS-E386 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human BARD1 Protein - H00000580-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BARD1-Antibody-N-term-Blocking-peptide - BP10664a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BARD1 Blocking Peptide - abx062036 from Abbexa Category Peptide Species Human

BARD1 - H00000580-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BARD1 - H00000580-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BARD1 fusion protein - ag18782 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

BARD1 fusion protein - Ag18965 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human BARD1 - BARD1-26645TH from Creative Biomart Category Protein Source Wheat germ Species Human

BARD1 Blocking Peptide - CBP3142 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

BARD1 (R8) Peptide - BS2408P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human BRCA1-associated RING domain protein 1(BARD1) - CSB-YP860351HU CSB-EP860351HU CSB-BP860351HU CSB-MP860351HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BARD1 (1-300) - sc-4355 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

BRCA1-Associated Protein 2, Peptide - MBS658520 from MyBioSource Category Protein Prices $290.00 Sizes 1 mg Species Human, Rodent

BRCA1-Associated Protein 2, Peptide - MBS658138 from MyBioSource Category Protein Prices $290.00 Sizes 1 mg Species Human, Rodent

BARD1 Recombinant Protein Antigen - NBP2-47543PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

BARD1 Blocking Peptide (OESA09421) - OESA09421 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

BARD1 Peptide, Human - M34GP01323H from Creative Peptides Category Peptide Source Synthetic. Species Human

BARD1 Recombinant Protein Antigen - NBP2-55593PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

BRCA1-associated RING domain protein 1 (BARD1), Recombinant Protein - MBS1361482 from MyBioSource Category Protein Prices $1,595.00, $1,595.00, $1,825.00, $1,825.00, $2,755.00, $2,755.00, $3,195.00, $3,195.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human BARD1 protein, GST-tagged - BARD1-074H from Creative Biomart Category Protein Source Wheat Germ Species Human

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