| Gene Symbol |
THOC1
|
| Entrez Gene |
9984
|
| Alt Symbol |
HPR1, P84, P84N5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
THO complex 1
|
| Other Description |
THO complex subunit 1|hTREX84|nuclear matrix protein p84|tho1
|
| Swissprots |
Q15219 Q64I72 Q96FV9 Q64I73 B2RBP6
|
| Accessions |
EAX01731 EAX01732 EAX01733 EAX01734 Q96FV9 AK055354 AK123530 AK225067 AK225709 AK314755 BAG37293 AY573302 AAT81408 AY573303 AAT81409 BC010381 AAH10381 DA902294 DQ892768 ABM83694 EU176747 ABW03548 L36529 AAA53571 XM_011525772 XP_011524074 XM_011525773 XP_011524075 XM_011525774 XP_011524076 NM_005131 NP_005122
|
| Function |
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.
|
| Subcellular Location |
Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.
|
| Tissue Specificity |
Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression. {ECO:0000269|PubMed:15358532, ECO:0000269|PubMed:15833825}.
|
| Top Pathways |
Spliceosome, RNA transport
|