THOC1

Gene Symbol	THOC1
Entrez Gene	9984
Alt Symbol	HPR1, P84, P84N5
Species	Human
Gene Type	protein-coding
Description	THO complex 1
Other Description	THO complex subunit 1|hTREX84|nuclear matrix protein p84|tho1
Swissprots	Q15219 Q64I72 Q96FV9 Q64I73 B2RBP6
Accessions	EAX01731 EAX01732 EAX01733 EAX01734 Q96FV9 AK055354 AK123530 AK225067 AK225709 AK314755 BAG37293 AY573302 AAT81408 AY573303 AAT81409 BC010381 AAH10381 DA902294 DQ892768 ABM83694 EU176747 ABW03548 L36529 AAA53571 XM_011525772 XP_011524074 XM_011525773 XP_011524075 XM_011525774 XP_011524076 NM_005131 NP_005122
Function	Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.
Subcellular Location	Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.
Tissue Specificity	Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression. {ECO:0000269|PubMed:15358532, ECO:0000269|PubMed:15833825}.
Top Pathways	Spliceosome, RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nuclear Matrix Protein p84 protein fragment - ab153034 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human hHpr1-p84-Thoc1 Protein - H00009984-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

THOC1-Antibody-C-term-Blocking-Peptide - BP16257b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

THOC1 Blocking Peptide - 33R-9212 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

THOC1 - H00009984-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

THOC1 - H00009984-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

THOC1 fusion protein - Ag1352 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human THOC1, GST-tagged - THOC1-3220H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human THO complex subunit 1(THOC1) - CSB-YP853419HU CSB-EP853419HU CSB-BP853419HU CSB-MP853419HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

THOC1 Protein - abx163487 from Abbexa Category Protein Species Human, Mouse, Rat

THOC1 - TP303117 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

THO complex subunit 1 (THOC1), Recombinant Protein - MBS1359158 from MyBioSource Category Protein Prices $1,455.00, $1,455.00, $1,685.00, $1,685.00, $2,480.00, $2,480.00, $2,920.00, $2,920.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

hHpr1-p84-Thoc1 Recombinant Protein Antigen - NBP1-89670PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

hHpr1-p84-Thoc1 Recombinant Protein Antigen - NBP1-89669PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

THOC1 Peptide, Human - M34GP15913H from Creative Peptides Category Peptide Source Synthetic. Species Human

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